| Title |
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii
|
|---|---|
| Published in |
Probiotics and Antimicrobial Proteins, July 2018
|
| DOI | 10.1007/s12602-018-9444-5 |
| Pubmed ID | |
| Authors |
Maciej Jaśkiewicz, Damian Neubauer, Kamil Kazor, Sylwia Bartoszewska, Wojciech Kamysz |
| Abstract |
Acinetobacter baumannii is one of the most challenging pathogens, on account of its predisposition to develop resistance leading to severe, difficult-to-treat infections. As these bacteria are more usually isolated from nosocomial infections, the new therapeutic options are demanded. Antimicrobial peptides (AMPs) are compounds likely to find application in the treatment of A. baumannii. These compounds exhibit a wide spectrum of antimicrobial activity and were found to be effective against biofilm. In this study, eight AMPs, namely aurein 1.2, CAMEL, citropin 1.1., LL-37, omiganan, r-omiganan, pexiganan, and temporin A, were tested for their antimicrobial activity. A reference strain of A. baumannii ATCC 19606 was used. Antimicrobial assays included determination of the minimum inhibitory concentration and the minimum biofilm eradication concentration. Considering the fact that the majority of A. baumannii infections are associated with mechanical ventilation and the use of indwelling devices, the activity against biofilm was assessed on both a polystyrene surface and tracheal tube fragments. In addition, cytotoxicity (HaCaT) was determined and in vitro selectivity index was calculated. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 19% |
| Student > Master | 10 | 14% |
| Student > Bachelor | 7 | 9% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 23 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Medicine and Dentistry | 8 | 11% |
| Immunology and Microbiology | 8 | 11% |
| Agricultural and Biological Sciences | 8 | 11% |
| Chemical Engineering | 3 | 4% |
| Other | 12 | 16% |
| Unknown | 22 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#20,527,576
of 23,096,849 outputs
Outputs from Probiotics and Antimicrobial Proteins
#401
of 548 outputs
Outputs of similar age
#288,196
of 329,806 outputs
Outputs of similar age from Probiotics and Antimicrobial Proteins
#14
of 22 outputs
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So far Altmetric has tracked 548 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.