| Title |
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data
|
|---|---|
| Published in |
Intensive Care Medicine, July 2018
|
| DOI | 10.1007/s00134-018-5327-1 |
| Pubmed ID | |
| Authors |
Matthieu Jabaudon, Raiko Blondonnet, Bruno Pereira, Rodrigo Cartin-Ceba, Christoph Lichtenstern, Tommaso Mauri, Rogier M. Determann, Tomas Drabek, Rolf D. Hubmayr, Ognjen Gajic, Florian Uhle, Andrea Coppadoro, Antonio Pesenti, Marcus J. Schultz, Marco V. Ranieri, Helena Brodska, Ségolène Mrozek, Vincent Sapin, Michael A. Matthay, Jean-Michel Constantin, Carolyn S. Calfee |
| Abstract |
The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury. We conducted a meta-analysis of individual data from 746 patients enrolled in eight prospective randomized and observational studies in which plasma sRAGE was measured in ARDS articles published through March 2016. The primary outcome was 90-day mortality. Using multivariate and mediation analyses, we tested the association between baseline plasma sRAGE and mortality, independently of driving pressure and tidal volume. Higher baseline plasma sRAGE [odds ratio (OR) for each one-log increment, 1.18; 95% confidence interval (CI) 1.01-1.38; P = 0.04], driving pressure (OR for each one-point increment, 1.04; 95% CI 1.02-1.07; P = 0.002), and tidal volume (OR for each one-log increment, 1.98; 95% CI 1.07-3.64; P = 0.03) were independently associated with higher 90-day mortality in multivariate analysis. Baseline plasma sRAGE mediated a small fraction of the effect of higher ΔP on mortality but not that of higher VT. Higher baseline plasma sRAGE was associated with higher 90-day mortality in patients with ARDS, independently of driving pressure and tidal volume, thus reinforcing the likely contribution of alveolar epithelial injury as an important prognostic factor in ARDS. Registration: PROSPERO (ID: CRD42018100241). |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 7 | 29% |
| United States | 3 | 13% |
| Australia | 1 | 4% |
| Malaysia | 1 | 4% |
| Denmark | 1 | 4% |
| United Kingdom | 1 | 4% |
| Unknown | 10 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 58% |
| Practitioners (doctors, other healthcare professionals) | 6 | 25% |
| Scientists | 4 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 93 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 17% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Master | 9 | 10% |
| Professor > Associate Professor | 6 | 6% |
| Professor | 5 | 5% |
| Other | 19 | 20% |
| Unknown | 27 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 45% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Nursing and Health Professions | 3 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Computer Science | 1 | 1% |
| Other | 11 | 12% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2020.
All research outputs
#2,686,420
of 23,607,611 outputs
Outputs from Intensive Care Medicine
#1,793
of 5,105 outputs
Outputs of similar age
#54,889
of 331,112 outputs
Outputs of similar age from Intensive Care Medicine
#53
of 123 outputs
Altmetric has tracked 23,607,611 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,105 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.