You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
|
|---|---|
| Published in |
Cell, July 2018
|
| DOI | 10.1016/j.cell.2018.06.017 |
| Pubmed ID | |
| Authors |
Leah V. Sibener, Ricardo A. Fernandes, Elizabeth M. Kolawole, Catherine B. Carbone, Fan Liu, Darren McAffee, Michael E. Birnbaum, Xinbo Yang, Laura F. Su, Wong Yu, Shen Dong, Marvin H. Gee, Kevin M. Jude, Mark M. Davis, Jay T. Groves, William A. Goddard, James R. Heath, Brian D. Evavold, Ronald D. Vale, K. Christopher Garcia |
| Abstract |
TCR-signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high frequency in the human T cell repertoire. Here, we studied human TCRs that are refractory to activation by pMHC ligands despite robust binding. Analysis of 3D affinity, 2D dwell time, and crystal structures of stimulatory versus non-stimulatory TCR-pMHC interactions failed to account for their different signaling outcomes. Using yeast pMHC display, we identified peptide agonists of a formerly non-responsive TCR. Single-molecule force measurements demonstrated the emergence of catch bonds in the activating TCR-pMHC interactions, correlating with exclusion of CD45 from the TCR-APC contact site. Molecular dynamics simulations of TCR-pMHC disengagement distinguished agonist from non-agonist ligands based on the acquisition of catch bonds within the TCR-pMHC interface. The isolation of catch bonds as a parameter mediating the coupling of TCR binding and signaling has important implications for TCR and antigen engineering for immunotherapy. |
X Demographics
The data shown below were collected from the profiles of 79 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 26 | 33% |
| United Kingdom | 8 | 10% |
| France | 4 | 5% |
| Germany | 3 | 4% |
| Austria | 2 | 3% |
| Singapore | 1 | 1% |
| Sweden | 1 | 1% |
| South Africa | 1 | 1% |
| Iraq | 1 | 1% |
| Other | 7 | 9% |
| Unknown | 25 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 46 | 58% |
| Scientists | 29 | 37% |
| Practitioners (doctors, other healthcare professionals) | 3 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 433 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 433 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 122 | 28% |
| Researcher | 73 | 17% |
| Other | 33 | 8% |
| Student > Bachelor | 31 | 7% |
| Student > Doctoral Student | 29 | 7% |
| Other | 61 | 14% |
| Unknown | 84 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 99 | 23% |
| Immunology and Microbiology | 91 | 21% |
| Agricultural and Biological Sciences | 51 | 12% |
| Chemistry | 28 | 6% |
| Engineering | 22 | 5% |
| Other | 47 | 11% |
| Unknown | 95 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2023.
All research outputs
#747,164
of 25,552,933 outputs
Outputs from Cell
#3,220
of 17,225 outputs
Outputs of similar age
#16,065
of 342,010 outputs
Outputs of similar age from Cell
#88
of 163 outputs
Altmetric has tracked 25,552,933 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,225 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,010 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.