| Title |
Zika Virus and the Metabolism of Neuronal Cells
|
|---|---|
| Published in |
Molecular Neurobiology, July 2018
|
| DOI | 10.1007/s12035-018-1263-x |
| Pubmed ID | |
| Authors |
Hussin A. Rothan, Shengyun Fang, Mohan Mahesh, Siddappa N. Byrareddy |
| Abstract |
Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. This process requires a controlled cellular metabolism that is essential for normal migration, axonal elongation, and dendrite morphogenesis of newly generated neurons. Thus, the remarkable changes in the cellular metabolism during early stages of neuronal stem cell differentiation are crucial for brain development. Recent studies show that ZIKV directly infects neuronal stem cells in the fetus and impairs brain growth. In this review, we highlighted the fact that the activation of P53 and inhibition of the mTOR pathway by ZIKV infection to neuronal stem cells induces early shifting from glycolysis to oxidative phosphorylation (OXPHOS) may induce immature differentiation, apoptosis, and stem cell exhaustion. We hypothesize that ZIKV infection to mature myelin-producing cells and resulting metabolic shift may lead to the development of neurological diseases, such as Guillain-Barré syndrome. Thus, the effects of ZIKV on the cellular metabolism of neuronal cells may lead to the incidence of neurological disorders as observed recently during ZIKV infection. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 19% |
| Student > Ph. D. Student | 20 | 17% |
| Student > Bachelor | 18 | 15% |
| Researcher | 12 | 10% |
| Student > Doctoral Student | 5 | 4% |
| Other | 13 | 11% |
| Unknown | 27 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 17% |
| Agricultural and Biological Sciences | 15 | 13% |
| Medicine and Dentistry | 14 | 12% |
| Immunology and Microbiology | 13 | 11% |
| Neuroscience | 8 | 7% |
| Other | 13 | 11% |
| Unknown | 34 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
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#20,527,576
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Outputs from Molecular Neurobiology
#2,829
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Outputs of similar age
#288,196
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Outputs of similar age from Molecular Neurobiology
#116
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