| Title |
Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy
|
|---|---|
| Published in |
Gastric Cancer, September 2015
|
| DOI | 10.1007/s10120-015-0546-4 |
| Pubmed ID | |
| Authors |
Yasunari Fukuda, Kazuyoshi Yamamoto, Motohiro Hirao, Kazuhiro Nishikawa, Yukiko Nagatsuma, Tamaki Nakayama, Sugano Tanikawa, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto, Kazumasa Fujitani, Toshimasa Tsujinaka |
| Abstract |
Malignancy is a secondary cause of sarcopenia, which is associated with impaired cancer treatment outcomes. The aim of this study was to investigate the prevalence of preoperative sarcopenia among elderly gastric cancer patients undergoing gastrectomy and the differences in preoperative dietary intake and postoperative complications between sarcopenic and non-sarcopenic patients. Ninety-nine patients over 65 years of age who underwent gastrectomy for gastric cancer were analyzed. All patients underwent gait and handgrip strength testing, and whole-body skeletal muscle mass was measured using a bioimpedance analysis technique based on the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm for the evaluation of sarcopenia before surgery. Preoperative dietary intake was assessed using a food frequency questionnaire. Of these patients, 21 (21.2 %) were diagnosed with sarcopenia. Sarcopenic patients consumed fewer calories and less protein preoperatively (23.9 vs. 27.8 kcal/kg ideal weight/day and 0.86 vs. 1.04 g/kg ideal weight/day; P = 0.001 and 0.0005, respectively). Although the overall incidence of postoperative complications was similar in the two groups (57.1 % vs. 35.9 %; P = 0.08), the incidence of severe (Clavien-Dindo grade ≥ IIIa) complications was significantly higher in the sarcopenic group than in the non-sarcopenic group (28.6 % vs. 9.0 %; P = 0.029). In the multivariate analysis, sarcopenia alone was identified as a risk factor for severe postoperative complications (odds ratio, 4.76; 95 % confidence interval, 1.03-24.30; P = 0.046). Preoperative sarcopenia as defined by the EWGSOP algorithm is a risk factor for severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 164 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 14% |
| Student > Master | 17 | 10% |
| Student > Bachelor | 16 | 10% |
| Other | 15 | 9% |
| Researcher | 13 | 8% |
| Other | 31 | 19% |
| Unknown | 51 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 69 | 42% |
| Nursing and Health Professions | 11 | 7% |
| Agricultural and Biological Sciences | 7 | 4% |
| Sports and Recreations | 5 | 3% |
| Psychology | 3 | 2% |
| Other | 10 | 6% |
| Unknown | 61 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2015.
All research outputs
#14,825,907
of 22,829,083 outputs
Outputs from Gastric Cancer
#293
of 597 outputs
Outputs of similar age
#151,832
of 274,965 outputs
Outputs of similar age from Gastric Cancer
#10
of 19 outputs
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.