| Title |
Association of Amine-Receptor DNA Sequence Variants with Associative Learning in the Honeybee
|
|---|---|
| Published in |
Behavior Genetics, September 2015
|
| DOI | 10.1007/s10519-015-9749-z |
| Pubmed ID | |
| Authors |
Malgorzata Lagisz, Alison R. Mercer, Charlotte de Mouzon, Luana L. S. Santos, Shinichi Nakagawa |
| Abstract |
Octopamine- and dopamine-based neuromodulatory systems play a critical role in learning and learning-related behaviour in insects. To further our understanding of these systems and resulting phenotypes, we quantified DNA sequence variations at six loci coding octopamine-and dopamine-receptors and their association with aversive and appetitive learning traits in a population of honeybees. We identified 79 polymorphic sequence markers (mostly SNPs and a few insertions/deletions) located within or close to six candidate genes. Intriguingly, we found that levels of sequence variation in the protein-coding regions studied were low, indicating that sequence variation in the coding regions of receptor genes critical to learning and memory is strongly selected against. Non-coding and upstream regions of the same genes, however, were less conserved and sequence variations in these regions were weakly associated with between-individual differences in learning-related traits. While these associations do not directly imply a specific molecular mechanism, they suggest that the cross-talk between dopamine and octopamine signalling pathways may influence olfactory learning and memory in the honeybee. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 28% |
| Researcher | 8 | 22% |
| Student > Ph. D. Student | 7 | 19% |
| Student > Doctoral Student | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Other | 1 | 3% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 61% |
| Psychology | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Neuroscience | 1 | 3% |
| Unknown | 6 | 17% |
Attention Score in Context
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#18,427,608
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Outputs from Behavior Genetics
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Outputs of similar age from Behavior Genetics
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