| Title |
Nucleolus and chromatin
|
|---|---|
| Published in |
Histochemistry and Cell Biology, July 2018
|
| DOI | 10.1007/s00418-018-1696-3 |
| Pubmed ID | |
| Authors |
Christian Schöfer, Klara Weipoltshammer |
| Abstract |
The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus organizer regions (NORs). In interphase cells, rDNA can be found inside and adjacent to nucleoli and the location is indicative for transcriptional activity of ribosomal genes-inactive rDNA (outside) versus active one (inside). Moreover, the nucleolus itself acts as a spatial organizer of non-nucleolar chromatin. Microscopy-based approaches offer the possibility to explore the spatially distinct localization of the different DNA populations in relation to the nucleolar structure. Recent technical developments in microscopy and preparatory methods may further our understanding of the functional architecture of nucleoli. This review will attempt to summarize the current understanding of mammalian nucleolar chromatin organization as seen from a microscopist's perspective. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 137 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 21% |
| Researcher | 17 | 12% |
| Student > Master | 15 | 11% |
| Student > Bachelor | 15 | 11% |
| Professor | 8 | 6% |
| Other | 23 | 17% |
| Unknown | 30 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 55 | 40% |
| Agricultural and Biological Sciences | 22 | 16% |
| Medicine and Dentistry | 8 | 6% |
| Computer Science | 3 | 2% |
| Neuroscience | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 37 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2018.
All research outputs
#15,907,830
of 24,217,893 outputs
Outputs from Histochemistry and Cell Biology
#570
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Outputs of similar age
#202,840
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Outputs of similar age from Histochemistry and Cell Biology
#13
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