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Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

Overview of attention for article published in Scientific Reports, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
4 news outlets

Citations

dimensions_citation
72 Dimensions

Readers on

mendeley
188 Mendeley
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Title
Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
Published in
Scientific Reports, September 2015
DOI 10.1038/srep14624
Pubmed ID
Authors

Sabine Hellwig, Annette Masuch, Sigrun Nestel, Natalie Katzmarski, Melanie Meyer-Luehmann, Knut Biber

Abstract

The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation. We found that microglia ingested Aβ, thereby preventing plaque formation in OHSCs. Conversely, Aβ deposits formed rapidly in microglia-free wild-type slices. The capacity to prevent Aβ plaque formation was absent in forebrain microglia from young adult but not juvenile 5xFamilial Alzheimer's disease (FAD) mice. Since no loss of Aβ clearance capacity was observed in both wild-type and cerebellar microglia from 5xFAD animals, the high Aβ1-42 burden in the forebrain of 5xFAD animals likely underlies the exhaustion of microglial Aβ clearance capacity. These data may therefore explain why Aβ plaque formation has never been described in wild-type mice, and point to a beneficial role of microglia in AD pathology. We also describe a new method to study Aβ plaque formation in a cell culture setting.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 2%
Portugal 2 1%
Korea, Republic of 1 <1%
Unknown 182 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 23%
Researcher 30 16%
Student > Bachelor 25 13%
Student > Master 19 10%
Student > Doctoral Student 14 7%
Other 23 12%
Unknown 34 18%
Readers by discipline Count As %
Neuroscience 55 29%
Agricultural and Biological Sciences 47 25%
Medicine and Dentistry 14 7%
Biochemistry, Genetics and Molecular Biology 13 7%
Immunology and Microbiology 6 3%
Other 11 6%
Unknown 42 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2015.
All research outputs
#1,200,163
of 23,323,574 outputs
Outputs from Scientific Reports
#11,873
of 126,097 outputs
Outputs of similar age
#18,376
of 275,536 outputs
Outputs of similar age from Scientific Reports
#249
of 2,276 outputs
Altmetric has tracked 23,323,574 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 126,097 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2,276 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.