| Title |
Altering the balance between healthy and mutated mitochondrial DNA
|
|---|---|
| Published in |
Journal of Inherited Metabolic Disease, May 2010
|
| DOI | 10.1007/s10545-010-9122-6 |
| Pubmed ID | |
| Authors |
Paul M. Smith, Robert N. Lightowlers |
| Abstract |
Pathogenic mutations of the mitochondrial genome are frequently found to co-exist with wild-type mtDNA molecules, a state known as heteroplasmy. In most disease cases, the mutation is recessive with manifestation of a clinical phenotype occurring when the proportion of mutated mtDNA exceeds a high threshold. The concept of increasing the ratio of healthy to mutated mtDNA as a means to correcting the biochemical defect has received much attention. A number of strategies are highlighted in this article, including manipulation of the mitochondrial genome by antigenomic drugs or restriction endonucleases, zinc finger peptide-targeted nucleases and exercise-induced gene shifting. The feasibility of these approaches has been demonstrated in a number of models, however more work is necessary before use in human patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 24% |
| Student > Bachelor | 8 | 17% |
| Researcher | 6 | 13% |
| Professor > Associate Professor | 6 | 13% |
| Student > Master | 5 | 11% |
| Other | 5 | 11% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 30% |
| Medicine and Dentistry | 10 | 22% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Neuroscience | 3 | 7% |
| Sports and Recreations | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 5 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2011.
All research outputs
#15,238,442
of 22,656,971 outputs
Outputs from Journal of Inherited Metabolic Disease
#1,463
of 1,831 outputs
Outputs of similar age
#77,606
of 95,730 outputs
Outputs of similar age from Journal of Inherited Metabolic Disease
#19
of 23 outputs
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So far Altmetric has tracked 1,831 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.