| Title |
Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial
|
|---|---|
| Published in |
Advances in Therapy, July 2018
|
| DOI | 10.1007/s12325-018-0746-5 |
| Pubmed ID | |
| Authors |
Norbert J. Tripolt, Slaven Stekovic, Felix Aberer, Jasmin Url, Peter N. Pferschy, Sabrina Schröder, Nicolas Verheyen, Albrecht Schmidt, Ewald Kolesnik, Sophie H. Narath, Regina Riedl, Barbara Obermayer-Pietsch, Thomas R. Pieber, Frank Madeo, Harald Sourij |
| Abstract |
Alternate day fasting (ADF) is a subtype of intermittent fasting and is defined as a continuous sequence of a fast day (100% energy restriction, zero calories) and a feed day (ad libitum food consumption), resulting in roughly 36-h fasting periods. Previous studies demonstrated weight reductions and improvements of cardiovascular risk factors with ADF in obese subjects. However, rigorous data on potential endocrine, metabolic and cardiovascular effects, besides weight loss, are lacking. Therefore we aim to investigate the short- and mid- to long-term clinical and molecular effects of ADF in healthy non-obese subjects. We will perform a prospective cohort study with an embedded randomized controlled trial (RCT) including 90 healthy subjects. Thirty of them will have performed ADF for at least 6 months (mid-term group). Sixty healthy subjects without a particular diet before enrolment will serve as the control group. These subjects will be 1:1 randomized to either continuing their current diet or performing ADF for 4 weeks. All subjects will undergo study procedures that will be repeated in RCT participants after 4 weeks. These procedures will include assessment of outcome parameters, dual-energy X-ray absorptiometry, measurement of endothelial function, an oral glucose tolerance test, 24-h blood pressure measurement, retinal vessel analysis, echocardiography and physical activity measurement by an accelerometer. Blood, sputum, buccal mucosa and faeces will be collected for laboratory analyses. Participants in the RCT will wear a continuous glucose monitor to verify adherence to the study intervention. The aim of this project is to investigate the effects of ADF on human physiology and molecular cellular processes. This investigation should gain in-depth mechanistic insights into the concept of ADF and form the basis for larger subsequent cohort recruitment and consecutive intervention studies. NCT02673515; registered 24 November 2015. Current protocol date/version: 7 February 2017/version 1.8. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 262 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 262 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 17% |
| Student > Master | 31 | 12% |
| Researcher | 22 | 8% |
| Student > Ph. D. Student | 21 | 8% |
| Student > Postgraduate | 14 | 5% |
| Other | 41 | 16% |
| Unknown | 88 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 20% |
| Nursing and Health Professions | 37 | 14% |
| Biochemistry, Genetics and Molecular Biology | 13 | 5% |
| Agricultural and Biological Sciences | 11 | 4% |
| Sports and Recreations | 11 | 4% |
| Other | 44 | 17% |
| Unknown | 94 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2020.
All research outputs
#13,386,534
of 23,098,660 outputs
Outputs from Advances in Therapy
#975
of 2,385 outputs
Outputs of similar age
#164,601
of 330,303 outputs
Outputs of similar age from Advances in Therapy
#10
of 48 outputs
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