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Sex-Related Reserve Hypothesis in Alzheimer’s Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up

Overview of attention for article published in Journal of Alzheimer's Disease, January 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 news outlet
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1 X user

Citations

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9 Dimensions

Readers on

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45 Mendeley
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Title
Sex-Related Reserve Hypothesis in Alzheimer’s Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up
Published in
Journal of Alzheimer's Disease, January 2018
DOI 10.3233/jad-180049
Pubmed ID
Authors

Juyoun Lee, Hanna Cho, Seun Jeon, Hee Jin Kim, Yeo Jin Kim, Jeongmin Lee, Sung Tae Kim, Jong-Min Lee, Juhee Chin, Samuel N Lockhart, Ae Young Lee, Duk L Na, Sang Won Seo

Abstract

Sex effects on the progression of Alzheimer's disease (AD) have received less attention than other demographic factors, including onset age and education. The aim of this study was to investigate whether sex affected cortical thinning in the disease progression of AD. We prospectively recruited 36 patients with early-stage AD and 14 people with normal cognition. All subjects were assessed with magnetic resonance imaging at baseline, Year 1, Year 3, and Year 5. We performed cortical thickness analyses using surface-based morphometry on magnetic resonance imaging. Women with AD showed more rapid cortical thinning in the left prefrontal cortex, bilateral medial frontal cortices, bilateral temporo-parietal association cortices, and bilateral lateral temporal lobe over 5 years than men with AD, even though there was no difference in cortical thickness at baseline. In contrast, there were no regions of significantly more rapid atrophy in men with AD. Our findings suggest that women deteriorate faster than men in the progression of AD.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 16%
Student > Ph. D. Student 5 11%
Student > Bachelor 4 9%
Student > Postgraduate 4 9%
Student > Master 4 9%
Other 5 11%
Unknown 16 36%
Readers by discipline Count As %
Neuroscience 8 18%
Medicine and Dentistry 7 16%
Psychology 4 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Social Sciences 2 4%
Other 2 4%
Unknown 20 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2018.
All research outputs
#3,711,927
of 25,385,509 outputs
Outputs from Journal of Alzheimer's Disease
#2,897
of 7,452 outputs
Outputs of similar age
#78,325
of 449,583 outputs
Outputs of similar age from Journal of Alzheimer's Disease
#216
of 543 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,452 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 543 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.