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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors
|
|---|---|
| Published in |
Cell Reports, October 2015
|
| DOI | 10.1016/j.celrep.2015.08.080 |
| Pubmed ID | |
| Authors |
Nurit Paz-Yaacov, Lily Bazak, Ilana Buchumenski, Hagit T. Porath, Miri Danan-Gotthold, Binyamin A. Knisbacher, Eli Eisenberg, Erez Y. Levanon |
| Abstract |
Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may change farther downstream. RNA editing alters the mRNA sequence from its genomic blueprint in a dynamic and flexible way. A few isolated cases of editing alterations in cancer have been reported previously. Here, we provide a transcriptome-wide characterization of RNA editing across hundreds of cancer samples from multiple cancer tissues, and we show that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types. Increased editing activity is found to be associated with patient survival. As is the case with somatic mutations in DNA, most of these newly introduced RNA mutations are likely passengers, but a few may serve as drivers that may be novel candidates for therapeutic and diagnostic purposes. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 37% |
| Germany | 1 | 5% |
| Belgium | 1 | 5% |
| Egypt | 1 | 5% |
| United Kingdom | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 7 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 53% |
| Scientists | 6 | 32% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Chile | 1 | <1% |
| South Africa | 1 | <1% |
| Norway | 1 | <1% |
| Denmark | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 260 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 22% |
| Researcher | 52 | 19% |
| Student > Bachelor | 27 | 10% |
| Student > Master | 26 | 10% |
| Student > Doctoral Student | 10 | 4% |
| Other | 31 | 12% |
| Unknown | 63 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 88 | 33% |
| Agricultural and Biological Sciences | 74 | 28% |
| Medicine and Dentistry | 13 | 5% |
| Computer Science | 6 | 2% |
| Immunology and Microbiology | 5 | 2% |
| Other | 14 | 5% |
| Unknown | 68 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2022.
All research outputs
#2,835,959
of 25,654,566 outputs
Outputs from Cell Reports
#5,978
of 13,165 outputs
Outputs of similar age
#37,335
of 287,483 outputs
Outputs of similar age from Cell Reports
#78
of 233 outputs
Altmetric has tracked 25,654,566 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,165 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.1. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,483 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.