Title |
Hsp90 regulates autophagy and plays a role in cancer therapy
|
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Published in |
Tumor Biology, October 2015
|
DOI | 10.1007/s13277-015-4142-3 |
Pubmed ID | |
Authors |
Benli Wang, Zongyan Chen, Feifei Yu, Qiao Chen, Yuxi Tian, Shumei Ma, Tiejun Wang, Xiaodong Liu |
Abstract |
Nowadays, heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, has become the target of antitumor drugs as a result of its close relationship with the occurrence and development, biological behavior, and prognosis of a tumor. Autophagy has attracted big attention recently for its paradoxical roles in cell survival and cell death, especially in the pathogenesis and treatment of cancer. Moreover, it has been verified that Hsp90 plays a role in autophagy via regulating the stability and activity of signaling proteins, and some Hsp90 inhibitors can induce autophagy. However, the underlying mechanisms for these important processes have not been clarified so far. In this study, we focus on the roles of Hsp90 in the regulation of autophagy, such as toll-like receptor (TLR)-mediated autophagy, Ulk1-mediated mitophagy, and chaperone-mediated autophagy (CMA). The roles of Hsp90 inhibitors in cancer therapy will also be elucidated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 28% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 9% |
Student > Master | 3 | 7% |
Other | 1 | 2% |
Other | 4 | 9% |
Unknown | 14 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 28% |
Agricultural and Biological Sciences | 8 | 19% |
Immunology and Microbiology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Unspecified | 1 | 2% |
Other | 2 | 5% |
Unknown | 17 | 40% |