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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months
|
|---|---|
| Published in |
PLOS ONE, October 2015
|
| DOI | 10.1371/journal.pone.0139082 |
| Pubmed ID | |
| Authors |
Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon M. Laws, David Ames, Kathryn A. Ellis, Stephanie R. Rainey-Smith, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff |
| Abstract |
High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE ε4 carrier status, and cognitive decline over 18 months, in 317 cognitively healthy (CN) older adults (47.6% males, 52.4% females) aged between 60 and 89 years (Mean = 69.9, SD = 6.8). Cognition was assessed using the Cogstate Brief Battery (CBB) and the California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN older adults with high Aβ who were also APOE ε4 carriers demonstrated the most pronounced decline in learning and working memory. In CN older adults who were APOE ε4 non-carriers, high Aβ was unrelated to cognitive decline in learning and working memory. Carriage of APOE ε4 in CN older adults with low Aβ was associated with a significantly increased rate of decline in learning and unexpectedly, improved cognitive performance on measures of verbal episodic memory over 18 months. These results suggest that Aβ and APOE ε4 interact to increase the rate of cognitive decline in CN older adults and provide further support for the use of Aβ and APOE ε4 as biomarkers of early Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Canada | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Researcher | 10 | 12% |
| Student > Bachelor | 10 | 12% |
| Other | 8 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 17 | 20% |
| Unknown | 18 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 27% |
| Neuroscience | 14 | 17% |
| Medicine and Dentistry | 10 | 12% |
| Agricultural and Biological Sciences | 8 | 10% |
| Nursing and Health Professions | 2 | 2% |
| Other | 8 | 10% |
| Unknown | 19 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2016.
All research outputs
#2,349,523
of 23,318,744 outputs
Outputs from PLOS ONE
#29,783
of 199,315 outputs
Outputs of similar age
#33,990
of 276,520 outputs
Outputs of similar age from PLOS ONE
#776
of 5,786 outputs
Altmetric has tracked 23,318,744 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 199,315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5,786 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.