Title |
MapMi: automated mapping of microRNA loci
|
---|---|
Published in |
BMC Bioinformatics, March 2010
|
DOI | 10.1186/1471-2105-11-133 |
Pubmed ID | |
Authors |
José Afonso Guerra-Assunção, Anton J Enright |
Abstract |
A large effort to discover microRNAs (miRNAs) has been under way. Currently miRBase is their primary repository, providing annotations of primary sequences, precursors and probable genomic loci. In many cases miRNAs are identical or very similar between related (or in some cases more distant) species. However, miRBase focuses on those species for which miRNAs have been directly confirmed. Secondly, specific miRNAs or their loci are sometimes not annotated even in well-covered species. We sought to address this problem by developing a computational system for automated mapping of miRNAs within and across species. Given the sequence of a known miRNA in one species it is relatively straightforward to determine likely loci of that miRNA in other species. Our primary goal is not the discovery of novel miRNAs but the mapping of validated miRNAs in one species to their most likely orthologues in other species. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 3% |
Germany | 3 | 3% |
Brazil | 3 | 3% |
Portugal | 1 | <1% |
Saudi Arabia | 1 | <1% |
United States | 1 | <1% |
Unknown | 102 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 28% |
Student > Ph. D. Student | 27 | 23% |
Professor > Associate Professor | 17 | 15% |
Student > Master | 8 | 7% |
Student > Postgraduate | 7 | 6% |
Other | 20 | 17% |
Unknown | 4 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 64 | 56% |
Biochemistry, Genetics and Molecular Biology | 24 | 21% |
Computer Science | 10 | 9% |
Medicine and Dentistry | 4 | 3% |
Business, Management and Accounting | 2 | 2% |
Other | 6 | 5% |
Unknown | 5 | 4% |