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Rho GTPases

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Cover of 'Rho GTPases'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Computational Modeling of the Dynamics of Spatiotemporal Rho GTPase Signaling: A Systematic Review
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    Chapter 2 Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation
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    Chapter 3 Modeling Rho GTPase Dynamics Using Boolean Logic
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    Chapter 4 EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity
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    Chapter 5 Applying Perturbation Expectation-Maximization to Protein Trajectories of Rho GTPases
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    Chapter 6 Parallel High-Resolution Imaging of Leukocyte Chemotaxis Under Agarose with Rho-Family GTPase Biosensors
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    Chapter 7 Characterization of Genetically Encoded FRET Biosensors for Rho-Family GTPases
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    Chapter 8 Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis
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    Chapter 9 An In Vitro Kinase Assay to Assess Rac1 Phosphorylation by ERK
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    Chapter 10 Methods to Study Rho GTPases Using Bacterial Toxins
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    Chapter 11 Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione
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    Chapter 12 High-Throughput Assay for RhoGEFs Based on the Transcreener® GDP Assay
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    Chapter 13 Small-Volume Flow Cytometry-Based Multiplex Analysis of the Activity of Small GTPases
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    Chapter 14 Methods to Study the Roles of Rho GTPases in Platelet Function
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    Chapter 15 Methods to Investigate the Role of Rho GTPases in Osteoclast Function
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    Chapter 16 Methods to Study the Role of Cdc42, Rac1, and Rac2 in B-Cell Cytoskeletal Responses
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    Chapter 17 In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells
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    Chapter 18 Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells
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    Chapter 19 C3 Transferase Gene Therapy for Continuous RhoA Inhibition
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    Chapter 20 A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells
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    Chapter 21 Methods to Study the Roles of Rho GTPases in Dendritic Tree Complexity
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    Chapter 22 Assessing the Roles of Rho GTPases in Cell DNA Repair by the Nucleotide Excision Repair Pathway
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    Chapter 23 Measuring the Contributions of the Rho Pathway to the DNA Damage Response in Tumor Epithelial Cells
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    Chapter 24 Using GAL4-Inducible Transgenics to Modulate Rho GTPase Activity in Zebrafish
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    Chapter 25 Assaying Rho GTPase-Dependent Processes in Dictyostelium discoideum
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    Chapter 26 Reconstruction of ROP GTPase Domains on the Plasma Membrane in Tobacco Leaves
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    Chapter 27 Analyzing Rho GTPase-Dependent Processes During Cell Polarization in Brown Algae
Attention for Chapter 18: Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells
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Chapter title
Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells
Chapter number 18
Book title
Rho GTPases
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8612-5_18
Pubmed ID
Book ISBNs
978-1-4939-8611-8, 978-1-4939-8612-5
Authors

Benjamin Mizukawa, Eric O’Brien, James C. Mulloy, Yi Zheng, Mizukawa, Benjamin, O’Brien, Eric, Mulloy, James C., Zheng, Yi

Abstract

Cdc42 was originally discovered as a key regulator of bud site assembly and polarity in S. cerevisiae. Recent genetic studies have shown that the function of Cdc42 in regulating cell polarity appears highly conserved from budding yeast to humans. The role of Cdc42 in hematopoietic cell transformation and leukemia progression has been studied in an acute myeloid leukemia model using the MLL-AF9 oncogene-induced transformation and a Cdc42 conditional gene-targeted mouse model. Here we describe the leukemia cell polarity and division symmetry assays in the context of leukemia cell fate determination.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2018.
All research outputs
#15,161,914
of 23,318,744 outputs
Outputs from Methods in molecular biology
#4,839
of 13,323 outputs
Outputs of similar age
#257,555
of 444,001 outputs
Outputs of similar age from Methods in molecular biology
#513
of 1,502 outputs
Altmetric has tracked 23,318,744 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,323 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 1,502 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.