| Title |
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, July 2018
|
| DOI | 10.1007/s10549-018-4895-7 |
| Pubmed ID | |
| Authors |
Tara Sanft, Ilana Usiskin, Maura Harrigan, Brenda Cartmel, Lingeng Lu, Fang-Yong Li, Yang Zhou, Anees Chagpar, Leah M. Ferrucci, Lajos Pusztai, Melinda L. Irwin |
| Abstract |
Some studies suggest that telomere shortening may be associated with increased breast cancer risk and mortality. Obesity is also associated with increased breast cancer risk and mortality. Few studies have examined changes in telomere length in overweight or obese breast cancer survivors. The purpose of our study was to examine the effect of a 6-month diet- and exercise-induced weight loss intervention versus usual care on telomere length in breast cancer survivors. 151 breast cancer survivors with body mass index (BMI) ≥ 25 kg/m2 were randomly assigned to a 6-month weight loss intervention (n = 93) or to usual care (n = 58). Fasting blood samples, height, weight, physical activity, and diet were measured at baseline and 6-months. Relative telomere length (RTL) was measured by quantitative-polymerase chain reaction (qPCR) done on buffy coat-extracted genomic DNA. Mean baseline to 6-month changes were compared between groups (intention-to-treat) using generalized estimating equations. Complete telomere data were available in 125 participants. Women were 58 ± 8 years, with BMI 33.0 ± 6.2 kg/m2 and were 2.9 ± 2.5 years from diagnosis; 90% were non-Hispanic white, and 76% had stage 0/I breast cancer. After 6 months, women randomized to weight loss had 3% telomere lengthening compared to 5% shortening in the usual care group (p = 0.12). Among women with stage 0/I, the intervention group experienced 7% telomere lengthening compared to 8% shortening in the usual care group (p = 0.01). No intervention effect was observed in women with stage II/III breast cancer. Our findings suggest a weight loss intervention in stage 0 and 1 breast cancer survivors may lead to telomere lengthening, compared to a shortening in their usual care counterparts. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 25% |
| United States | 3 | 15% |
| United Kingdom | 2 | 10% |
| Austria | 1 | 5% |
| Canada | 1 | 5% |
| Greece | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 65% |
| Practitioners (doctors, other healthcare professionals) | 5 | 25% |
| Scientists | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | <1% |
| Unknown | 181 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 13% |
| Student > Bachelor | 20 | 11% |
| Researcher | 17 | 9% |
| Student > Ph. D. Student | 15 | 8% |
| Student > Doctoral Student | 14 | 8% |
| Other | 36 | 20% |
| Unknown | 57 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 21% |
| Nursing and Health Professions | 30 | 16% |
| Sports and Recreations | 15 | 8% |
| Biochemistry, Genetics and Molecular Biology | 9 | 5% |
| Agricultural and Biological Sciences | 4 | 2% |
| Other | 19 | 10% |
| Unknown | 67 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2021.
All research outputs
#1,051,183
of 23,098,660 outputs
Outputs from Breast Cancer Research and Treatment
#116
of 4,688 outputs
Outputs of similar age
#24,432
of 329,967 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#2
of 49 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,688 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,967 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.