Title |
Architecture of the Mouse Brain Synaptome
|
---|---|
Published in |
Neuron, August 2018
|
DOI | 10.1016/j.neuron.2018.07.007 |
Pubmed ID | |
Authors |
Fei Zhu, Mélissa Cizeron, Zhen Qiu, Ruth Benavides-Piccione, Maksym V. Kopanitsa, Nathan G. Skene, Babis Koniaris, Javier DeFelipe, Erik Fransén, Noboru H. Komiyama, Seth G.N. Grant |
Abstract |
Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of a billion synapses. Each synapse subtype showed a unique anatomical distribution, and each brain region showed a distinct signature of synapse subtypes. Whole-brain synaptome cartography revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatiotemporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain the greatest synapse diversity, and mutations causing cognitive disorders reorganized synaptome maps. Synaptome technology and resources have wide-ranging application in studies of the normal and diseased brain. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 64 | 26% |
United Kingdom | 23 | 9% |
Canada | 10 | 4% |
Spain | 6 | 2% |
Australia | 6 | 2% |
France | 5 | 2% |
Netherlands | 4 | 2% |
Ireland | 4 | 2% |
Japan | 3 | 1% |
Other | 29 | 12% |
Unknown | 90 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 166 | 68% |
Scientists | 72 | 30% |
Practitioners (doctors, other healthcare professionals) | 5 | 2% |
Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 606 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 146 | 24% |
Researcher | 123 | 20% |
Student > Master | 60 | 10% |
Student > Bachelor | 52 | 9% |
Student > Doctoral Student | 27 | 4% |
Other | 78 | 13% |
Unknown | 120 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 235 | 39% |
Agricultural and Biological Sciences | 79 | 13% |
Biochemistry, Genetics and Molecular Biology | 50 | 8% |
Medicine and Dentistry | 28 | 5% |
Chemistry | 13 | 2% |
Other | 54 | 9% |
Unknown | 147 | 24% |