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Architecture of the Mouse Brain Synaptome

Overview of attention for article published in Neuron, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 9,562)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Citations

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170 Dimensions

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606 Mendeley
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Title
Architecture of the Mouse Brain Synaptome
Published in
Neuron, August 2018
DOI 10.1016/j.neuron.2018.07.007
Pubmed ID
Authors

Fei Zhu, Mélissa Cizeron, Zhen Qiu, Ruth Benavides-Piccione, Maksym V. Kopanitsa, Nathan G. Skene, Babis Koniaris, Javier DeFelipe, Erik Fransén, Noboru H. Komiyama, Seth G.N. Grant

Abstract

Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of a billion synapses. Each synapse subtype showed a unique anatomical distribution, and each brain region showed a distinct signature of synapse subtypes. Whole-brain synaptome cartography revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatiotemporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain the greatest synapse diversity, and mutations causing cognitive disorders reorganized synaptome maps. Synaptome technology and resources have wide-ranging application in studies of the normal and diseased brain.

X Demographics

X Demographics

The data shown below were collected from the profiles of 244 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 606 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 606 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 146 24%
Researcher 123 20%
Student > Master 60 10%
Student > Bachelor 52 9%
Student > Doctoral Student 27 4%
Other 78 13%
Unknown 120 20%
Readers by discipline Count As %
Neuroscience 235 39%
Agricultural and Biological Sciences 79 13%
Biochemistry, Genetics and Molecular Biology 50 8%
Medicine and Dentistry 28 5%
Chemistry 13 2%
Other 54 9%
Unknown 147 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 766. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2022.
All research outputs
#25,639
of 25,571,620 outputs
Outputs from Neuron
#30
of 9,562 outputs
Outputs of similar age
#485
of 342,414 outputs
Outputs of similar age from Neuron
#4
of 123 outputs
Altmetric has tracked 25,571,620 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,562 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,414 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.