| Title |
The rationale for deep brain stimulation in Alzheimer’s disease
|
|---|---|
| Published in |
Journal of Neural Transmission, October 2015
|
| DOI | 10.1007/s00702-015-1462-9 |
| Pubmed ID | |
| Authors |
Zaman Mirzadeh, Ausaf Bari, Andres M. Lozano |
| Abstract |
Alzheimer's disease is a major worldwide health problem with no effective therapy. Deep brain stimulation (DBS) has emerged as a useful therapy for certain movement disorders and is increasingly being investigated for treatment of other neural circuit disorders. Here we review the rationale for investigating DBS as a therapy for Alzheimer's disease. Phase I clinical trials of DBS targeting memory circuits in Alzheimer's disease patients have shown promising results in clinical assessments of cognitive function, neurophysiological tests of cortical glucose metabolism, and neuroanatomical volumetric measurements showing reduced rates of atrophy. These findings have been supported by animal studies, where electrical stimulation of multiple nodes within the memory circuit have shown neuroplasticity through stimulation-enhanced hippocampal neurogenesis and improved performance in memory tasks. The precise mechanisms by which DBS may enhance memory and cognitive functions in Alzheimer's disease patients and the degree of its clinical efficacy continue to be examined in ongoing clinical trials. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 100 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 20% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 9 | 9% |
| Professor | 8 | 8% |
| Other | 21 | 21% |
| Unknown | 18 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 19% |
| Medicine and Dentistry | 18 | 18% |
| Agricultural and Biological Sciences | 12 | 12% |
| Psychology | 11 | 11% |
| Engineering | 6 | 6% |
| Other | 11 | 11% |
| Unknown | 25 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2017.
All research outputs
#2,880,480
of 22,829,683 outputs
Outputs from Journal of Neural Transmission
#158
of 1,766 outputs
Outputs of similar age
#41,517
of 277,991 outputs
Outputs of similar age from Journal of Neural Transmission
#1
of 27 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,991 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.