Title |
Chemical screen identifies a geroprotective role of quercetin in premature aging
|
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Published in |
Protein & Cell, August 2018
|
DOI | 10.1007/s13238-018-0567-y |
Pubmed ID | |
Authors |
Lingling Geng, Zunpeng Liu, Weiqi Zhang, Wei Li, Zeming Wu, Wei Wang, Ruotong Ren, Yao Su, Peichang Wang, Liang Sun, Zhenyu Ju, Piu Chan, Moshi Song, Jing Qu, Guang-Hui Liu |
Abstract |
Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 22% |
Bolivia, Plurinational State of | 1 | 11% |
Norway | 1 | 11% |
France | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 89% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 101 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 16% |
Researcher | 14 | 14% |
Student > Bachelor | 9 | 9% |
Student > Doctoral Student | 7 | 7% |
Student > Master | 7 | 7% |
Other | 15 | 15% |
Unknown | 33 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 23 | 23% |
Agricultural and Biological Sciences | 13 | 13% |
Medicine and Dentistry | 10 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Chemistry | 4 | 4% |
Other | 10 | 10% |
Unknown | 35 | 35% |