Title |
Characterisation of inflammatory processes in Helicobacter pylori -induced gastric lymphomagenesis in a mouse model
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Published in |
Oncotarget, October 2015
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DOI | 10.18632/oncotarget.5948 |
Pubmed ID | |
Authors |
Pauline Floch, Amandine Marine Laur, Victoria Korolik, Delphine Chrisment, David Cappellen, Yamina Idrissi, Pierre Dubus, Francis Mégraud, Philippe Lehours |
Abstract |
Gastric MALT lymphoma (GML) can be induced by Helicobacter pylori infection in BALB/c mice thymectomised at day 3 post-birth (d3Tx). This represented a unique opportunity to investigate the inflammatory process involved in the recruitment, proliferation and structuration of lymphoid infiltrates in the gastric mucosa of mice developing GML. Complementary molecular and proteomic approaches demonstrated that Th1 and Th2 cytokines were upregulated, along with activators/regulators of the lymphoid response and numerous chemokines. Interleukin-4, interferon γ, lymphotoxin-α and -β were significantly upregulated and correlated with the inflammatory scores for all the d3Tx mice. GML lesions in d3Tx mice infected with H. pylori were associated with the presence of the inflammatory response. The dysregulation of numerous members of the tumour necrosis factor superfamily was also evident and suggests that they could play an important role in GML pathology, especially in light of their ability to promote and control lymphocyte proliferation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 29% |
Student > Master | 3 | 21% |
Researcher | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 14% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 43% |
Biochemistry, Genetics and Molecular Biology | 4 | 29% |
Immunology and Microbiology | 3 | 21% |
Unknown | 1 | 7% |