Title |
Genetic characterization of chikungunya viruses isolated during the 2015-2017 outbreaks in different states of India, based on their E1 and E2 genes
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Published in |
Archives of Virology, August 2018
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DOI | 10.1007/s00705-018-3974-8 |
Pubmed ID | |
Authors |
Jayashri Patil, Ashwini More, Poonam Patil, Santosh Jadhav, Priyanka Newase, Megha Agarwal, Sarika Amdekar, C. G. Raut, Deepti Parashar, Sarah S. Cherian |
Abstract |
During 2015-2017, chikungunya virus (CHIKV) showed a resurgence in several parts of India with Karnataka, Maharashtra and New Delhi accounting for a majority of the cases. E2-E1 gene based characterization revealed Indian subcontinent sublineage strains possessing Aedes aegypti mosquito-adaptive mutations E1: K211E and E2:V264A, with the 211 site positively selected. Novel mutational sites E1: K16E/Q, E1: K132Q/T, E1: S355T, E2: C19R and E2:S185Y could be associated with epitopes or virulence determining domains. The study examines the role of host, vector and viral factors and fills gaps in our molecular epidemiology data for these regions which are known to possess a dynamic population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Ecuador | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 19% |
Researcher | 5 | 14% |
Student > Doctoral Student | 4 | 11% |
Student > Master | 3 | 8% |
Student > Postgraduate | 2 | 5% |
Other | 5 | 14% |
Unknown | 11 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 22% |
Agricultural and Biological Sciences | 6 | 16% |
Immunology and Microbiology | 4 | 11% |
Medicine and Dentistry | 3 | 8% |
Unspecified | 1 | 3% |
Other | 4 | 11% |
Unknown | 11 | 30% |