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X Demographics
Mendeley readers
Attention Score in Context
| Title |
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
|
|---|---|
| Published in |
Molecular Cell, October 2015
|
| DOI | 10.1016/j.molcel.2015.09.002 |
| Pubmed ID | |
| Authors |
Feng Liu, Gary C. Hon, Genaro R. Villa, Kristen M. Turner, Shiro Ikegami, Huijun Yang, Zhen Ye, Bin Li, Samantha Kuan, Ah Young Lee, Ciro Zanca, Bowen Wei, Greg Lucey, David Jenkins, Wei Zhang, Cathy L. Barr, Frank B. Furnari, Timothy F. Cloughesy, William H. Yong, Timothy C. Gahman, Andrew K. Shiau, Webster K. Cavenee, Bing Ren, Paul S. Mischel |
| Abstract |
Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, genotyped clinical samples, and TCGA data, we show that EGFR mutations remodel the activated enhancer landscape of GBM, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regulatory network in vitro and in vivo. The most common EGFR mutation, EGFRvIII, sensitizes GBM cells to the BET-bromodomain inhibitor JQ1 in a SOX9, FOXG1-dependent manner. These results identify the role of transcriptional/epigenetic remodeling in EGFR-dependent pathogenesis and suggest a mechanistic basis for epigenetic therapy. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 33% |
| Congo | 1 | 4% |
| United Kingdom | 1 | 4% |
| France | 1 | 4% |
| Brazil | 1 | 4% |
| Belgium | 1 | 4% |
| Unknown | 11 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 54% |
| Scientists | 9 | 38% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 242 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Hungary | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 237 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 24% |
| Researcher | 45 | 19% |
| Student > Master | 21 | 9% |
| Student > Bachelor | 20 | 8% |
| Student > Doctoral Student | 12 | 5% |
| Other | 40 | 17% |
| Unknown | 45 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 76 | 31% |
| Agricultural and Biological Sciences | 53 | 22% |
| Medicine and Dentistry | 31 | 13% |
| Neuroscience | 10 | 4% |
| Engineering | 5 | 2% |
| Other | 18 | 7% |
| Unknown | 49 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2016.
All research outputs
#818,046
of 25,402,528 outputs
Outputs from Molecular Cell
#732
of 7,624 outputs
Outputs of similar age
#12,051
of 290,064 outputs
Outputs of similar age from Molecular Cell
#13
of 95 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,624 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.