| Title |
Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, October 2015
|
| DOI | 10.1007/s10585-015-9755-9 |
| Pubmed ID | |
| Authors |
Mauricio Rodriguez-Torres, Alison L. Allan |
| Abstract |
There is accumulating evidence indicating that aldehyde dehydrogenase (ALDH) activity selects for cancer cells with increased aggressiveness, capacity for sustained proliferation, and plasticity in primary tumors. However, emerging data also suggests an important mechanistic role for the ALDH family of isoenzymes in the metastatic activity of tumor cells. Recent studies indicate that ALDH correlates with either increased or decreased metastatic capacity in a cellular context-dependent manner. Importantly, it appears that different ALDH isoforms support increased metastatic capacity in different tumor types. This review assesses the potential of ALDH as biological marker and mechanistic mediator of metastasis in solid tumors. In many malignancies, most notably in breast cancer, ALDH activity and expression appears to be a promising marker and potential therapeutic target for treating metastasis in the clinical setting. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| China | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 122 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 21% |
| Researcher | 20 | 16% |
| Student > Master | 12 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Student > Bachelor | 10 | 8% |
| Other | 15 | 12% |
| Unknown | 33 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 22% |
| Agricultural and Biological Sciences | 23 | 18% |
| Medicine and Dentistry | 21 | 17% |
| Chemistry | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2022.
All research outputs
#7,660,617
of 23,854,458 outputs
Outputs from Clinical & Experimental Metastasis
#199
of 778 outputs
Outputs of similar age
#91,602
of 281,426 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#6
of 17 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 778 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.