| Title |
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
|
|---|---|
| Published in |
JACC: Basic to Translational Science, August 2018
|
| DOI | 10.1016/j.jacbts.2018.04.001 |
| Pubmed ID | |
| Authors |
Ljubica Perisic Matic, Maria Jesus Iglesias, Mattias Vesterlund, Mariette Lengquist, Mun-Gwan Hong, Shanga Saieed, Laura Sanchez-Rivera, Martin Berg, Anton Razuvaev, Malin Kronqvist, Kent Lund, Kenneth Caidahl, Peter Gillgren, Fredrik Pontén, Mathias Uhlén, Jochen M. Schwenk, Göran K. Hansson, Gabrielle Paulsson-Berne, Erika Fagman, Joy Roy, Rebecka Hultgren, Göran Bergström, Janne Lehtiö, Jacob Odeberg, Ulf Hedin |
| Abstract |
Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| Sweden | 2 | 20% |
| France | 1 | 10% |
| Germany | 1 | 10% |
| Netherlands | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Science communicators (journalists, bloggers, editors) | 2 | 20% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 17% |
| Researcher | 10 | 16% |
| Student > Bachelor | 8 | 13% |
| Professor > Associate Professor | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 18 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 12 | 19% |
| Agricultural and Biological Sciences | 6 | 9% |
| Neuroscience | 3 | 5% |
| Chemistry | 3 | 5% |
| Other | 6 | 9% |
| Unknown | 20 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#4,100,411
of 25,461,852 outputs
Outputs from JACC: Basic to Translational Science
#317
of 806 outputs
Outputs of similar age
#72,512
of 342,115 outputs
Outputs of similar age from JACC: Basic to Translational Science
#12
of 20 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 806 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,115 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.