Title |
IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients
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Published in |
Tumor Biology, October 2015
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DOI | 10.1007/s13277-015-4186-4 |
Pubmed ID | |
Authors |
Ahmed-Amine Zergoun, Abderezak Zebboudj, Sarah Leila Sellam, Nora Kariche, Djamel Djennaoui, Samir Ouraghi, Esma Kerboua, Zine-Charaf Amir-Tidadini, Dalia Chilla, Fatima Asselah, Chafia Touil-Boukoffa, Taha Merghoub, Mehdi Bourouba |
Abstract |
The role of nitric oxide (NO)(·) in the development of the metastatic properties of nasopharyngeal carcinoma (NPC) is not fully understood. Previous studies proposed that interleukin-6 (IL-6) would act as regulator of matrix metalloprotease activation in NPC. Recently, we showed that (NO)(·) was a critical mediator of tumor growth in patients. The aim of this study was to determine the implication of IL-6 in the progression of NPC pathology via metalloprotease (MMP) activation and their possible correlation with (NO)(·) production. We observed a significant increase in IL-6 and nitrite (NO2 (-)) synthesis in patients (n = 17) as well as a strong expression of IL-6 and nitric oxide synthase 2 (NOS2) in the analyzed tumors (n = 8). In patients' plasma, a negative correlation associated IL-6 with circulating nitrites (r = -0.33). A negative correlation associated the H-scores of these signals in the tumors (r = -0.47). In patients' plasma, nitrite synthesis was positively associated with MMP-9 activation (r = 0.45), pro-MMP-2 expression (r = 0.37), and negatively correlated with MMP-2 activation (r = -0.51). High nitrite levels was associated with better recurrence-free survival (RFS) (p = 0.02). Overall, our results suggest that the IL-6/NOS2 inflammatory signals are involved in the regulation of MMP-9- and MMP-2-dependent metastatic activity and that high circulating nitrite levels in NPC patients may constitute a prognostic predictor for survival. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 22% |
Researcher | 2 | 11% |
Professor | 1 | 6% |
Other | 1 | 6% |
Lecturer | 1 | 6% |
Other | 1 | 6% |
Unknown | 8 | 44% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Agricultural and Biological Sciences | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 9 | 50% |