| Title |
Glucocorticoids in multiple myeloma: past, present, and future
|
|---|---|
| Published in |
Annals of Hematology, August 2018
|
| DOI | 10.1007/s00277-018-3465-8 |
| Pubmed ID | |
| Authors |
Nicholas Burwick, Sanjai Sharma |
| Abstract |
Glucocorticoids are a backbone of treatment for multiple myeloma in both the upfront and relapsed/refractory setting. While glucocorticoids have single agent activity in multiple myeloma, in the modern era, they are paired with novel agents to induce high clinical response rates. On the other hand, toxicities of steroid therapy limit high dose delivery and impact patient quality of life. We provide a history of steroid use in multiple myeloma with the aim to understand how steroids have emerged and persisted in the treatment of multiple myeloma. We review mechanisms of glucocorticoid sensitivity and resistance and highlight potential future directions to evaluate steroid responsiveness. Further research in this area will aid in optimizing steroid utilization and help determine when glucocorticoid therapy may no longer benefit patients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| Thailand | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 15% |
| Student > Bachelor | 14 | 14% |
| Student > Ph. D. Student | 8 | 8% |
| Researcher | 7 | 7% |
| Student > Doctoral Student | 6 | 6% |
| Other | 8 | 8% |
| Unknown | 41 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 20% |
| Medicine and Dentistry | 17 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Immunology and Microbiology | 5 | 5% |
| Nursing and Health Professions | 1 | 1% |
| Other | 7 | 7% |
| Unknown | 41 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2023.
All research outputs
#4,225,128
of 24,762,960 outputs
Outputs from Annals of Hematology
#183
of 2,348 outputs
Outputs of similar age
#76,230
of 336,181 outputs
Outputs of similar age from Annals of Hematology
#10
of 52 outputs
Altmetric has tracked 24,762,960 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,348 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.