Title |
Carving out another slice of the pie: Exceptional response to single agent imatinib in an asian female never-smoker with advanced NSCLC with a de-novo PDGFR-α N848 K mutation
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Published in |
Lung Cancer (01695002), July 2018
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DOI | 10.1016/j.lungcan.2018.07.043 |
Pubmed ID | |
Authors |
Samuel J. Klempner, Kyle Gowen, Thomas K. Lee, Viola W. Zhu, Alexa B. Schrock, Vincent A. Miller, Siraj M. Ali, Sai-Hong Ignatius Ou |
Abstract |
Non-small cell lung cancer (NSCLC) has emerged as a paradigm for clinical application of precision medicine as optimal therapy is commonly chosen based on genomic biomarkers identified in a patient's tumor sample. Recurrent driver alterations are well described, however, a need to continually identify rare variants remains clinically relevant. We identified an incident case of advanced NSCLC with a PDGFR-α N848 K activation loop mutation with no other concurrent oncogenic drivers. Amino acid sequence alignment confirmed homology to the imatinib-sensitive KIT N822 K activation loop mutation observed in GIST. The patient achieved a 2-year response to single agent imatinib that is ongoing. While PDGFR-α N848 K is rare among public sequencing databases our cases strongly suggests functional relevance and highlights the importance of studying rare variants in NSCLC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 15% |
Researcher | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Librarian | 1 | 4% |
Student > Doctoral Student | 1 | 4% |
Other | 2 | 7% |
Unknown | 13 | 48% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Social Sciences | 1 | 4% |
Psychology | 1 | 4% |
Other | 0 | 0% |
Unknown | 14 | 52% |