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Mendeley readers
| Title |
Will intrafraction repair have negative consequences on extreme hypofractionation in prostate radiation therapy?
|
|---|---|
| Published in |
British Journal of Radiology, October 2015
|
| DOI | 10.1259/bjr.20150588 |
| Pubmed ID | |
| Authors |
Alexandru Dasu, Iuliana Toma-Dasu |
| Abstract |
The present study aims to investigate the impact of increasing fraction delivery time on the outcome of hypofractionated radiation therapy for prostate cancer. Mono-exponential and bi-exponential repair models have been used for prostate patients to study the loss of biochemical control at 5 years for several clinically-relevant irradiation times. The theoretical predictions were compared with newly reported clinical results from 4607 patients undergoing conventionally-fractionated and hypofractionated prostate radiation therapy. Time-demanding irradiation techniques appear to lead to biochemical control rates that sometimes are about 10-20 percentage points below predictions that neglect intra-fraction repair. This difference appears to be of the same order of magnitude as that predicted by moderately-slow to slow repair taking place during the irradiation time. The impact is largest for the patient risk groups receiving doses corresponding to the steepest part of the dose-response curve. In contrast, for treatment techniques requiring irradiation times shorter than about 20 minutes, the impact of intra-fraction repair appears to be much smaller and probably difficult to be observed in the light of other sources of uncertainty in clinical data. Neglecting intra-fraction repair might overestimate the effectiveness of some treatment schedules and could also influence any subsequent estimations of fractionation sensitivity for prostate tumours. Advances in knowledge: The effect of intra-fraction repair for prostate cancer should be taken into account for long irradiation sessions as might be expected from scanned beams and/or from multiple intra-fraction imaging sessions to check the positioning of the patient. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 3 | 16% |
| Researcher | 3 | 16% |
| Student > Postgraduate | 2 | 11% |
| Student > Master | 2 | 11% |
| Student > Ph. D. Student | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 5 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 37% |
| Physics and Astronomy | 3 | 16% |
| Computer Science | 1 | 5% |
| Psychology | 1 | 5% |
| Unknown | 7 | 37% |