| Title |
Comparison of Human Primary with Human iPS Cell-Derived Dopaminergic Neuron Grafts in the Rat Model for Parkinson’s Disease
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, October 2015
|
| DOI | 10.1007/s12015-015-9623-7 |
| Pubmed ID | |
| Authors |
Su-Ping Peng, Sjef Copray |
| Abstract |
Neuronal degeneration within the substantia nigra and the loss of the dopaminergic nigro-striatal pathway are the major hallmarks of Parkinson's disease (PD). Grafts of foetal ventral mesencephalic (VM) dopaminergic (DA) neurons into the striatum have been shown to be able to restore striatal dopamine levels and to improve overall PD symptoms. However, human foetus-derived cell grafts are not feasible for clinical application. Autologous induced pluripotent stem cell (iPS cell)-derived DA neurons are emerging as an unprecedented alternative. In this review, we summarize and compare the efficacy of human iPS cell-derived DA neuron grafts to restore normal behaviour in a rat model for PD with that of human foetal primary DA neurons. The differences we observed in the efficacy to restore normal function between the 2 types of DA neuron grafts could be ascribed to intrinsic properties of the iPS cell-derived DA neurons that critically affected survival and proper neurite extension in the striatum after implantation. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 26% |
| Student > Master | 14 | 22% |
| Researcher | 11 | 17% |
| Student > Bachelor | 6 | 9% |
| Student > Doctoral Student | 2 | 3% |
| Other | 9 | 14% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 23% |
| Biochemistry, Genetics and Molecular Biology | 14 | 22% |
| Neuroscience | 12 | 18% |
| Medicine and Dentistry | 8 | 12% |
| Engineering | 4 | 6% |
| Other | 4 | 6% |
| Unknown | 8 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2018.
All research outputs
#2,759,542
of 25,371,288 outputs
Outputs from Stem Cell Reviews and Reports
#62
of 1,035 outputs
Outputs of similar age
#37,049
of 289,641 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#1
of 16 outputs
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So far Altmetric has tracked 1,035 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.