| Title |
Circulating DNA as biomarker in breast cancer
|
|---|---|
| Published in |
Breast Cancer Research, October 2015
|
| DOI | 10.1186/s13058-015-0645-5 |
| Pubmed ID | |
| Authors |
Heidi Schwarzenbach, Klaus Pantel |
| Abstract |
As the release of tumor-associated DNA into blood circulation is a common event in patients with cancer, screening of plasma or serum DNA may provide information on genetic and epigenetic profiles associated with breast cancer development, progression, and response to therapy. Quantitative testing of circulating DNA can reflect tumor burden, and molecular characterization of circulating DNA can reveal important tumor characteristics relevant to the choice of targeted therapies in individual patients. Contrary to circulating DNA from blood that presents molecular changes in tumor DNA in real time, tissue biopsies can deliver only a spatially and temporally limited snapshot of the heterogeneous tumor. Analyses of circulating DNA might provide prognostic and predictive information and therefore advance personalized medicine. However, standardization of different technical platforms as well as the control of pre-analytical and analytical factors is mandatory before its introduction into clinical practice. In the present review, we discussed technical aspects and clinical relevance of the analyses of circulating plasma/serum DNA in patients with breast cancer. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| United Kingdom | 2 | 14% |
| Ireland | 1 | 7% |
| Brazil | 1 | 7% |
| France | 1 | 7% |
| Unknown | 5 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 50% |
| Scientists | 3 | 21% |
| Practitioners (doctors, other healthcare professionals) | 3 | 21% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Ireland | 1 | <1% |
| Italy | 1 | <1% |
| Ecuador | 1 | <1% |
| Uruguay | 1 | <1% |
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Unknown | 173 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 17% |
| Researcher | 28 | 15% |
| Student > Master | 22 | 12% |
| Student > Bachelor | 19 | 10% |
| Other | 13 | 7% |
| Other | 35 | 19% |
| Unknown | 33 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 49 | 27% |
| Medicine and Dentistry | 35 | 19% |
| Agricultural and Biological Sciences | 28 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Chemistry | 5 | 3% |
| Other | 13 | 7% |
| Unknown | 45 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#2,305,110
of 25,373,627 outputs
Outputs from Breast Cancer Research
#221
of 2,052 outputs
Outputs of similar age
#31,648
of 290,709 outputs
Outputs of similar age from Breast Cancer Research
#4
of 27 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.