Title |
Adrenocortical neoplasia: evolving concepts in tumorigenesis with an emphasis on adrenal cortical carcinoma variants
|
---|---|
Published in |
Virchows Archiv, November 2011
|
DOI | 10.1007/s00428-011-1166-y |
Pubmed ID | |
Authors |
Ronald R. de Krijger, Thomas G. Papathomas |
Abstract |
Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis. According to WHO classification 2004, ACC variants include oncocytic ACCs, myxoid ACCs and ACCs with sarcomatous areas. Herein, we provide a comprehensive review of these rare subtypes of adrenocortical malignancy and emphasize their clinicopathological features with the aim of elucidating aspects of diagnostic categorization, differential diagnostics and biological behavior. The issue of current terminology, applied to biphasic tumors with pleomorphic, sarcomatous or sarcomatoid elements arising in adrenal cortex, is also discussed. We additionally present emerging evidence concerning the adrenal cortical tumorigenesis and the putative adenoma-carcinoma sequence as well. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 20% |
Other | 8 | 18% |
Student > Bachelor | 7 | 16% |
Researcher | 7 | 16% |
Professor > Associate Professor | 3 | 7% |
Other | 5 | 11% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 51% |
Agricultural and Biological Sciences | 5 | 11% |
Psychology | 2 | 4% |
Chemistry | 2 | 4% |
Computer Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 8 | 18% |