| Title |
A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women
|
|---|---|
| Published in |
European Journal of Nutrition, October 2015
|
| DOI | 10.1007/s00394-015-1060-5 |
| Pubmed ID | |
| Authors |
C. E. Storniolo, R. Casillas, M. Bulló, O. Castañer, E. Ros, G. T. Sáez, E. Toledo, R. Estruch, V. Ruiz-Gutiérrez, M. Fitó, M. A. Martínez-González, J. Salas-Salvadó, M. T. Mitjavila, J. J. Moreno |
| Abstract |
Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control. Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured. Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP. The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| Switzerland | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | <1% |
| Unknown | 230 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 36 | 16% |
| Researcher | 27 | 12% |
| Student > Master | 25 | 11% |
| Student > Ph. D. Student | 22 | 9% |
| Student > Doctoral Student | 17 | 7% |
| Other | 42 | 18% |
| Unknown | 63 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 25% |
| Nursing and Health Professions | 27 | 12% |
| Agricultural and Biological Sciences | 23 | 10% |
| Biochemistry, Genetics and Molecular Biology | 18 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
| Other | 18 | 8% |
| Unknown | 78 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 198. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2023.
All research outputs
#201,051
of 25,498,750 outputs
Outputs from European Journal of Nutrition
#74
of 2,706 outputs
Outputs of similar age
#2,647
of 290,301 outputs
Outputs of similar age from European Journal of Nutrition
#3
of 63 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,706 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,301 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.