| Title |
Cannabidiol-treated Rats Exhibited Higher Motor Score After Cryogenic Spinal Cord Injury
|
|---|---|
| Published in |
Neurotoxicity Research, September 2011
|
| DOI | 10.1007/s12640-011-9273-8 |
| Pubmed ID | |
| Authors |
Marcelo Kwiatkoski, Francisco Silveira Guimarães, Elaine Del-Bel |
| Abstract |
Cannabidiol (CBD), a non-psychoactive constituent of cannabis, has been reported to induce neuroprotective effects in several experimental models of brain injury. We aimed at investigating whether this drug could also improve locomotor recovery of rats submitted to spinal cord cryoinjury. Rats were distributed into five experimental groups. Animals were submitted to laminectomy in vertebral segment T10 followed or not by application of liquid nitrogen for 5 s into the spinal cord at the same level to cause cryoinjury. The animals received injections of vehicle or CBD (20 mg/kg) immediately before, 3 h after and daily for 6 days after surgery. The Basso, Beattie, and Bresnahan motor evaluation test was used to assess motor function post-lesion one day before surgery and on the first, third, and seventh postoperative days. The extent of injury was evaluated by hematoxylin-eosin histology and FosB expression. Cryogenic lesion of the spinal cord resulted in a significant motor deficit. Cannabidiol-treated rats exhibited a higher Basso, Beattie, and Bresnahan locomotor score at the end of the first week after spinal cord injury: lesion + vehicle, day 1: zero, day 7: four, and lesion + Cannabidiol 20 mg/kg, day 1: zero, day 7: seven. Moreover, at this moment there was a significant reduction in the extent of tissue injury and FosB expression in the ventral horn of the spinal cord. The present study confirmed that application of liquid nitrogen to the spinal cord induces reproducible and quantifiable spinal cord injury associated with locomotor function impairments. Cannabidiol improved locomotor functional recovery and reduced injury extent, suggesting that it could be useful in the treatment of spinal cord lesions. |
X Demographics
The data shown below were collected from the profiles of 91 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 72 | 79% |
| Canada | 6 | 7% |
| Cameroon | 1 | 1% |
| Unknown | 12 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 75 | 82% |
| Members of the public | 16 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| United Kingdom | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 48 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 15% |
| Researcher | 7 | 13% |
| Student > Master | 7 | 13% |
| Student > Ph. D. Student | 5 | 10% |
| Other | 4 | 8% |
| Other | 9 | 17% |
| Unknown | 12 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 23% |
| Neuroscience | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Medicine and Dentistry | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2019.
All research outputs
#596,821
of 24,383,935 outputs
Outputs from Neurotoxicity Research
#7
of 907 outputs
Outputs of similar age
#2,246
of 129,594 outputs
Outputs of similar age from Neurotoxicity Research
#2
of 8 outputs
Altmetric has tracked 24,383,935 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 907 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 99% of its peers.
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