| Title |
A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection
|
|---|---|
| Published in |
BMC Infectious Diseases, August 2018
|
| DOI | 10.1186/s12879-018-3253-z |
| Pubmed ID | |
| Authors |
Ilker Uçkay, Benjamin Kressmann, Sarah Malacarne, Anna Toumanova, Jaafar Jaafar, Daniel Lew, Benjamin A. Lipsky |
| Abstract |
An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens at the final visit. Regarding final clinical cure, there was no difference in favour of the gentamicin-sponges (26/45 vs. 31/43; p = 0.16). However, the gentamicin-sponge arm tended to a more rapid healing. In multivariate analysis adjusting for the case-mix, the variable "gentamicin-sponge" was not significantly associated with "cure and improvement". Gentamicin-sponges were very well tolerated, without any attributed adverse events. The gentamicin-sponge was very well tolerated, but did not significantly influence overall cure. ClinicalTrials.gov ( NCT01951768 ). Date 2 April 2013. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 33% |
| Venezuela, Bolivarian Republic of | 1 | 33% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 126 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 10% |
| Student > Master | 9 | 7% |
| Researcher | 7 | 6% |
| Student > Postgraduate | 6 | 5% |
| Student > Bachelor | 6 | 5% |
| Other | 22 | 17% |
| Unknown | 64 | 51% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 17% |
| Nursing and Health Professions | 19 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Engineering | 3 | 2% |
| Other | 10 | 8% |
| Unknown | 61 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2022.
All research outputs
#2,232,699
of 23,577,654 outputs
Outputs from BMC Infectious Diseases
#649
of 7,855 outputs
Outputs of similar age
#47,102
of 332,166 outputs
Outputs of similar age from BMC Infectious Diseases
#17
of 166 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,855 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.