| Title |
Efficacy of artesunate–amodiaquine in the treatment of falciparum uncomplicated malaria in Madagascar
|
|---|---|
| Published in |
Malaria Journal, August 2018
|
| DOI | 10.1186/s12936-018-2440-0 |
| Pubmed ID | |
| Authors |
Oméga Raobela, Valérie Andriantsoanirina, David Gael Rajaonera, Tovonahary Angelo Rakotomanga, Stéphane Rabearimanana, Fanomezantsoa Ralinoro, Didier Ménard, Arsène Ratsimbasoa |
| Abstract |
Since 2006, the artemisinin-based combination therapy (ACT) are recommended to treat uncomplicated malaria including non Plasmodium falciparum malaria in Madagascar. Artesunate-amodiaquine (ASAQ) and artemether-lumefantrine are the first- and second-line treatment in uncomplicated falciparum malaria, respectively. No clinical drug efficacy study has been published since 2009 to assess the efficacy of these two artemisinin-based combinations in Madagascar, although the incidence of malaria cases has increased from 2010 to 2016. In this context, new data about the efficacy of the drug combinations currently used to treat malaria are needed. Therapeutic efficacy studies evaluating the efficacy of ASAQ were conducted in 2012, 2013 and 2016 among falciparum malaria-infected patients aged between 6 months and 56 years, in health centres in 6 sites representing different epidemiological patterns. The 2009 World Health Organization protocol for monitoring anti-malarial drug efficacy was followed. A total of 348 enrolled patients met the inclusion criteria including 108 patients in 2012 (n = 64 for Matanga, n = 44 for Ampasipotsy), 123 patients in 2013 (n = 63 for Ankazomborona, n = 60 for Anjoma Ramartina) and 117 patients in 2016 (n = 67 for Tsaratanana, n = 50 for Antanimbary). The overall cumulative PCR-corrected day 28 cure rate was 99.70% (95% IC 98.30-99.95). No significant difference in cure rates was observed overtime: 99.02% (95% IC 94.65-99.83) in 2012; 100% (95% IC 96.8-100) in 2013 and 100% (95% IC 96.65-100) in 2016. The ASAQ combination remains highly effective for the treatment of uncomplicated falciparum malaria in Madagascar. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 12% |
| Researcher | 7 | 10% |
| Student > Ph. D. Student | 6 | 9% |
| Student > Bachelor | 3 | 4% |
| Unspecified | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 32 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Nursing and Health Professions | 4 | 6% |
| Agricultural and Biological Sciences | 4 | 6% |
| Unspecified | 3 | 4% |
| Medicine and Dentistry | 3 | 4% |
| Other | 12 | 18% |
| Unknown | 31 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#19,162,324
of 24,400,706 outputs
Outputs from Malaria Journal
#5,112
of 5,827 outputs
Outputs of similar age
#243,444
of 334,653 outputs
Outputs of similar age from Malaria Journal
#90
of 93 outputs
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