Title |
DNA methylation and detection of cervical cancer and precancerous lesions using molecular methods
|
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Published in |
Tumor Biology, October 2015
|
DOI | 10.1007/s13277-015-4197-1 |
Pubmed ID | |
Authors |
Sandra Mersakova, Marcela Nachajova, Peter Szepe, Petra Sumichrastova Kasajova, Erika Halasova |
Abstract |
Cervical cancer is the third most common cancer disease affecting the female population, and a key factor in the development of the disease is the human papillomavirus infection (HPV). The disease is also impacted by epigenetic changes such as DNA methylation, which causes activation or exclusion of certain genes. The aim of our review is to summarize and compare the most common molecular methods for detection of methylated promoter regions in biomarkers occurring in cervical carcinoma and also show the importance of connections of HR-HPV testing with methylation analysis in patients with cervical intraepithelial neoplasia. Insight into genetic and epigenetic alterations associated with cervical cancer development can offer opportunities for the molecular biomarkers that can be useful for screening, diagnosis, and also as new ways of treatment of cervical cancer precursor lesions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 18% |
Student > Bachelor | 7 | 18% |
Student > Master | 5 | 13% |
Researcher | 5 | 13% |
Student > Doctoral Student | 4 | 10% |
Other | 4 | 10% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 38% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Agricultural and Biological Sciences | 4 | 10% |
Immunology and Microbiology | 1 | 3% |
Physics and Astronomy | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 28% |