Title |
Recent advances in pulmonary arterial hypertension
|
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Published in |
F1000 Research, July 2018
|
DOI | 10.12688/f1000research.14984.1 |
Pubmed ID | |
Authors |
Martin R. Wilkins, Jurjan Aman, Lars Harbaum, Anna Ulrich, John Wharton, Christopher J. Rhodes |
Abstract |
Pulmonary arterial hypertension (PAH) is a rare disorder with a high mortality rate. Treatment options have improved in the last 20 years, but patients still die prematurely of right heart failure. Though rare, it is heterogeneous at the genetic and molecular level, and understanding and exploiting this is key to the development of more effective treatments. BMPR2, encoding bone morphogenetic receptor type 2, is the most commonly affected gene in both familial and non-familial PAH, but rare mutations have been identified in other genes. Transcriptomic, proteomic, and metabolomic studies looking for endophenotypes are under way. There is no shortage of candidate new drug targets for PAH, but the selection and prioritisation of these are challenges for the research community. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Student > Bachelor | 5 | 12% |
Researcher | 5 | 12% |
Student > Master | 4 | 9% |
Professor > Associate Professor | 3 | 7% |
Other | 7 | 16% |
Unknown | 12 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Medicine and Dentistry | 8 | 19% |
Agricultural and Biological Sciences | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Engineering | 2 | 5% |
Other | 2 | 5% |
Unknown | 16 | 37% |