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Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort

Overview of attention for article published in EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, October 2015
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Title
Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort
Published in
EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, October 2015
DOI 10.1289/ehp.1409238
Pubmed ID
Authors

Séverine Tual, Debra T. Silverman, Stella Koutros, Aaron Blair, Dale P. Sandler, Pierre Lebailly, Gabriella Andreotti, Jane A. Hoppin, Laura E. Beane Freeman

Abstract

Diesel exhaust is a known lung carcinogen. Farmers use a variety of dieselized equipment and thus may be at increased risk of lung cancer, but farm exposures such as endotoxins may also be protective for lung cancer. We evaluated the relative risk of incident lung cancer, including histological subtype, from enrollment (1993-1997) to 2010-2011 in relation to farm equipment use in the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators and spouses in Iowa and North Carolina, USA. Farm equipment use was reported by 21,273 farmers and 29,840 spouses. Rate ratios (RR) were estimated separately for farmers and spouses using Poisson regression models adjusted for smoking and other confounders. We conducted stratified analyses by exposure to animals or stored grain, a surrogate for endotoxin exposure. Daily diesel tractor use (versus no use) was positively associated with lung cancer in farmers (RR=1.48, 95% CI: 0.87, 2.50; 35 exposed, 32 unexposed cases), particularly adenocarcinoma (RR=3.39, 95% CI: 1.23, 9.33; 12 exposed, 7 unexposed cases). The association of adenocarcinoma with daily (versus low/no) use of diesel tractors was stronger for farmers with no animal or stored grain exposures (RR=6.23; 95% CI: 2.25, 17.25; 5 exposed, 18 unexposed cases) than among farmers with these exposures (RR=1.19; 95% CI: 0.51, 2.79; 7 exposed, 27 unexposed cases) (p-interaction=0.05). This study provides preliminary evidence of an increased risk of lung adenocarcinoma among daily drivers of diesel tractors and suggests that exposure to endotoxins may modify the impact of diesel exposure on lung cancer risk. Confirmation of these findings with more exposed cases and more detailed exposure information is warranted.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 12%
Student > Ph. D. Student 4 10%
Student > Doctoral Student 4 10%
Student > Bachelor 3 7%
Other 3 7%
Other 9 22%
Unknown 13 32%
Readers by discipline Count As %
Medicine and Dentistry 7 17%
Environmental Science 4 10%
Agricultural and Biological Sciences 4 10%
Nursing and Health Professions 2 5%
Social Sciences 2 5%
Other 6 15%
Unknown 16 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2015.
All research outputs
#20,660,571
of 25,377,790 outputs
Outputs from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#8,011
of 8,404 outputs
Outputs of similar age
#213,021
of 290,716 outputs
Outputs of similar age from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#46
of 53 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,404 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,716 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.