You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells*
|
|---|---|
| Published in |
Journal of Biological Chemistry, October 2015
|
| DOI | 10.1074/jbc.r115.685990 |
| Pubmed ID | |
| Authors |
Sidonia B G Eckle, Alexandra J Corbett, Andrew N Keller, Zhenjun Chen, Dale I Godfrey, Ligong Liu, Jeffrey Y W Mak, David P Fairlie, Jamie Rossjohn, James McCluskey |
| Abstract |
Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as Mucosal Associated Invariant T (MAIT) cells. The Major Histocompatibility class I-like antigen presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ TCRs) and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. Here we review our understanding of how these novel antigens are generated and discuss their interactions with MR1 and MAIT TCRs. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 75% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Thailand | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 133 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Researcher | 24 | 18% |
| Student > Bachelor | 13 | 9% |
| Student > Master | 11 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Other | 20 | 15% |
| Unknown | 36 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 33 | 24% |
| Agricultural and Biological Sciences | 22 | 16% |
| Biochemistry, Genetics and Molecular Biology | 18 | 13% |
| Medicine and Dentistry | 9 | 7% |
| Chemistry | 5 | 4% |
| Other | 11 | 8% |
| Unknown | 39 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2021.
All research outputs
#7,047,002
of 25,373,627 outputs
Outputs from Journal of Biological Chemistry
#29,166
of 85,238 outputs
Outputs of similar age
#79,831
of 291,142 outputs
Outputs of similar age from Journal of Biological Chemistry
#131
of 491 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 85,238 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 491 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.