| Title |
Nasopharyngeal oxygen therapy produces positive end-expiratory pressure in infants
|
|---|---|
| Published in |
European Journal of Pediatrics, June 2001
|
| DOI | 10.1007/s004310100798 |
| Pubmed ID | |
| Authors |
Bernhard Frey, Peter J. McQuillan, Frank Shann, Nicholas Freezer |
| Abstract |
The World Health Organisation recommends nasopharyngeal catheters as a safe and efficient method of oxygen administration in infants. However, little is known about the mechanisms of the improvement in oxygenation. The aim of the present study was to determine whether nasopharyngeal oxygen therapy produces positive end-expiratory pressure (PEEP). Nine spontaneously breathing infants (median age 13 months, range 10 days to 20 months) after heart surgery were investigated. All patients had normal pulmonary blood flow at the time of the study (Qp:Qs=1:1). Oxygen (oxygen fraction 1.0) was delivered by an 8 F catheter inserted into the nasopharynx (tip just visible below the soft palate). The pulmonary mechanics were analysed using a single compartment model of the respiratory system. Oesophageal pressure (Pes) at end-expiration, dynamic lung compliance (C(L)) and resistance (R(L)), minute ventilation, PaCO2 and PaO2 were measured at baseline without a nasopharyngeal catheter or oxygen, and at oxygen flows of 0.5 l/min, 1.0 l/min and 2.0 l/min. All the flows generated significant increases in PEEP. Mean difference in PEEP (SD, paired t-test versus baseline): 1.6 cm H2O (1.4, P=0.008) with 0.5 l/min of oxygen; 2.8 cm H2O (2.7, P=0.014) with 1.0 l/min of oxygen; and 4.0 cm H2O (2.9, P = 0.004) with 2.0 l/min of oxygen. There was a significant correlation between all the nasopharyngeal flows (in ml/kg per min) and the generated PEEP (P<0.001) and between the C(L) values and the generated PEEP (P < 0.05). There was no significant difference in PaCO2 and R(L). Minute ventilation was significantly less with nasopharyngeal oxygen than at baseline. As expected, PaO2 increased significantly with increasing oxygen flows. Administration of oxygen through an 8 F nasopharyngeal catheter at flow rates recommended by the World Health Organisation (0.5 l/min in newborns, 1.0 l/min in infants) produces moderate amounts of positive end-expiratory pressure. The levels achieved may contribute to an improvement in oxygenation by altering the visco-elastic properties of the lung. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 22% |
| Researcher | 3 | 13% |
| Student > Master | 3 | 13% |
| Student > Postgraduate | 2 | 9% |
| Lecturer | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 43% |
| Nursing and Health Professions | 4 | 17% |
| Unspecified | 1 | 4% |
| Psychology | 1 | 4% |
| Arts and Humanities | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 6 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2020.
All research outputs
#7,468,281
of 22,830,751 outputs
Outputs from European Journal of Pediatrics
#1,461
of 3,707 outputs
Outputs of similar age
#12,674
of 38,498 outputs
Outputs of similar age from European Journal of Pediatrics
#4
of 11 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,707 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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