Title |
Impact of the 2014 NIH chronic graft-versus-host disease scoring criteria modifications assessed in a large cohort of severely affected patients
|
---|---|
Published in |
Bone Marrow Transplantation, August 2018
|
DOI | 10.1038/s41409-018-0224-3 |
Pubmed ID | |
Authors |
Ana Zelic Kerep, Jacob Broome, Filip Pirsl, Lauren M. Curtis, Seth M. Steinberg, Sandra A. Mitchell, Edward W. Cowen, Dominique C. Pichard, Galen O. Joe, Leora E. Comis, Jacqueline W. Mays, Manuel B. Datiles, Pamela Stratton, Jessica Zolton, Ann Berger, Jennifer Hendricks, Megan Kenyon, Judy Baruffaldi, Irina Titarenko, Drazen Pulanic, Kristin Baird, Daniel H. Fowler, Ronald E. Gress, Steven Z. Pavletic |
Abstract |
In 2005, the National Institutes of Health (NIH) chronic graft-versus-host disease (cGVHD) consensus project provided diagnosis and staging criteria, based mostly on clinical experience and expert opinion. These criteria were revised in 2014, aiming to provide enhanced specificity and clarity. However, the impact of 2014 changes to the original NIH cGVHD severity scoring criteria has not been reported. In this study, 284 patients, prospectively enrolled on the National Cancer Institute's cross-sectional cGVHD natural history study, were scored using the 2005 NIH cGVHD criteria and then rescored according to the 2014 modifications. In comparing the two criteria, 2014 cGVHD global severity scoring resulted in a tendency toward being categorized as milder scores (75 vs. 72% of severe score per 2014, p = 0.0009), with a statistically significant shift in NIH liver and lung scores toward milder categories (p < 0.0001). 2005 and 2014 NIH global severity scores showed a significant association with reduced grip strength (p < 0.0001), reduced joint range of motion (p = 0.0003), and the subspecialist evaluation score (p < 0.0001). Poor survival prediction of the severe NIH lung score is also retained in the new criteria (p = 0.0012). These findings support the use of 2014 cGVHD scoring criteria in continuous efforts to develop better classification systems. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 11% |
Other | 5 | 9% |
Student > Bachelor | 5 | 9% |
Student > Master | 4 | 8% |
Researcher | 4 | 8% |
Other | 6 | 11% |
Unknown | 23 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 25% |
Nursing and Health Professions | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Arts and Humanities | 1 | 2% |
Other | 4 | 8% |
Unknown | 27 | 51% |