↓ Skip to main content

Testosterone plays a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats†

Overview of attention for article published in Biology of Reproduction, August 2018
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
6 X users

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
32 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Testosterone plays a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats†
Published in
Biology of Reproduction, August 2018
DOI 10.1093/biolre/ioy179
Pubmed ID
Authors

Jay S Mishra, Amar S More, Kathirvel Gopalakrishnan, Sathish Kumar

Abstract

Sex hormone-dependent vascular reactivity is an underlying factor contributing to sex differences in blood pressure. Inappropriate activation of the renin-angiotensin system (RAS) is involved in vascular dysfunction and hypertension. This study evaluated the role of androgens (testosterone) in angiotensin II (Ang II) -induced increase in blood pressure, vascular reactivity and cardiac hypertrophy. Eight weeks-old male Wistar rats underwent sham operation, castration, or castration with testosterone replacement. After 12 weeks of chronic changes in androgen status, Ang II (120 ng/kg per minute) or saline was infused for 28 days via subcutaneous miniosmotic pump, and changes in blood pressure was measured. Vascular reactivity and Ang II receptor levels were examined in mesenteric arteries. Heart weight, cardiac ANP mRNA levels and fibrosis were also assessed. Ang II infusion increased arterial pressure in intact males. The Ang II-induced increase in hypertensive response was prevented in castrated males. Testosterone replacement in castrated males restored Ang II-induced hypertensive responses. Castration reduced vascular AT1R/AT2R ratio, an effect that was reversed by testosterone replacement. Ang II-induced hypertension was associated with increased contractile response of mesenteric arteries to Ang II and phenylephrine in intact and testosterone-replaced castrated males; these increases were prevented in castrated males. Ang II infusion induced increased left ventricle-to-body weight ratio and ANP mRNA expression, indicators of left ventricular hypertrophy, and fibrosis in intact and testosterone-replaced castrated males, and castration prevented the increase in these parameters caused by Ang II. This study demonstrate that testosterone plays a permissive role in development and maintenance of Ang II-induced vascular dysfunction, hypertension and cardiac hypertrophy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 9%
Other 3 9%
Student > Bachelor 3 9%
Unspecified 2 6%
Lecturer 2 6%
Other 7 22%
Unknown 12 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 22%
Medicine and Dentistry 4 13%
Unspecified 2 6%
Psychology 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 13 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2020.
All research outputs
#8,196,482
of 25,397,764 outputs
Outputs from Biology of Reproduction
#1,265
of 4,935 outputs
Outputs of similar age
#130,148
of 341,062 outputs
Outputs of similar age from Biology of Reproduction
#16
of 52 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,935 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,062 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.