Title |
Impact of viral hepatitis co-infection on response to antiretroviral therapy and HIV disease progression in the HIV-NAT cohort
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Published in |
AIDS, May 2004
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DOI | 10.1097/00002030-200405210-00010 |
Pubmed ID | |
Authors |
W Phillip Law, Chris J Duncombe, Apicha Mahanontharit, Mark A Boyd, Kiat Ruxrungtham, Joep MA Lange, Praphan Phanuphak, David A Cooper, Gregory J Dore |
Abstract |
To examine the impact of viral hepatitis co-infection on HIV disease outcomes following commencement of combination antiretroviral therapy in a developing country setting. HIV RNA suppression, CD4 cell count recovery, and HIV disease progression were examined within a cohort of Thai HIV-infected patients enrolled in eight HIV-NAT randomized controlled trials of antiretroviral therapy (n = 692). Hepatitis B virus (HBV) and hepatitis C virus (HCV) testing was performed on stored serum. Mean age was 32.3 years, 52% were male, 11% had CDC category C HIV disease at baseline, and 22% had received prior antiretroviral therapy. Prevalence of HBV, HCV and HBV/HCV co-infection was 8.7, 7.2 and 0.4%, respectively. Median HIV RNA reductions (log10 copies/ml) were approximately 1.5 for HIV, HIV-HBV, HIV-HCV subgroups from week 4 up to week 48. Mean increases in CD4 cell count were significantly lower among HIV-HBV and HIV-HCV subgroups at week 4 (HIV, 62 x 10(6) cells/l; HIV-HBV, 29 x 10(6) cells/l; HIV-HCV, 33 x 10(6) cells/l), however, by week 48 CD4 cell increases were similar (HIV, 115 x 10(6) cells/l; HIV-HBV, 113 x 10(6) cells/l; HIV-HCV, 97 x 10(6) cells/l). Cox regression analyses showed that HIV-HBV or HIV-HCV co-infection were not associated with a CD4 cell count increase of 100 x 10(6) cells/l over 48 weeks. Estimated progression to AIDS event or death at week 48 was 3.3% (95% confidence interval, 2.0-5.1%) for HIV, 6.7% (2.5-14.6%) for HIV-HBV, and 8.0% (2.2-20.5%) for HIV-HCV subgroups (P > 0.05). An early delayed CD4 count recovery among HIV/viral hepatitis co-infected patients was not sustained, and was not associated with increased HIV disease progression. |
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Geographical breakdown
Country | Count | As % |
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Italy | 1 | 1% |
India | 1 | 1% |
Spain | 1 | 1% |
Greece | 1 | 1% |
United States | 1 | 1% |
Unknown | 86 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 16% |
Student > Master | 13 | 14% |
Student > Bachelor | 13 | 14% |
Student > Postgraduate | 8 | 9% |
Other | 7 | 8% |
Other | 20 | 22% |
Unknown | 15 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 45% |
Immunology and Microbiology | 8 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Agricultural and Biological Sciences | 5 | 5% |
Nursing and Health Professions | 4 | 4% |
Other | 9 | 10% |
Unknown | 18 | 20% |