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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals
|
|---|---|
| Published in |
Science, August 2018
|
| DOI | 10.1126/science.aap7714 |
| Pubmed ID | |
| Authors |
Wynn K Meyer, Jerrica Jamison, Rebecca Richter, Stacy E Woods, Raghavendran Partha, Amanda Kowalczyk, Charles Kronk, Maria Chikina, Robert K Bonde, Daniel E Crocker, Joseph Gaspard, Janet M Lanyon, Judit Marsillach, Clement E Furlong, Nathan L Clark |
| Abstract |
Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species' blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors' lipid metabolism and/or bloodstream oxidative environment affecting PON1's role in fatty acid oxidation. PON1 loss also eliminates marine mammals' main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environments. |
X Demographics
The data shown below were collected from the profiles of 155 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 46 | 30% |
| Spain | 12 | 8% |
| United Kingdom | 7 | 5% |
| Mexico | 7 | 5% |
| Australia | 4 | 3% |
| France | 3 | 2% |
| Germany | 2 | 1% |
| India | 1 | <1% |
| Canada | 1 | <1% |
| Other | 14 | 9% |
| Unknown | 58 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 97 | 63% |
| Scientists | 51 | 33% |
| Practitioners (doctors, other healthcare professionals) | 6 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 27% |
| Student > Master | 18 | 15% |
| Student > Bachelor | 18 | 15% |
| Researcher | 10 | 8% |
| Student > Doctoral Student | 5 | 4% |
| Other | 14 | 11% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 34% |
| Biochemistry, Genetics and Molecular Biology | 25 | 20% |
| Environmental Science | 11 | 9% |
| Chemistry | 4 | 3% |
| Veterinary Science and Veterinary Medicine | 3 | 2% |
| Other | 12 | 10% |
| Unknown | 27 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 274. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2024.
All research outputs
#132,957
of 25,728,855 outputs
Outputs from Science
#4,180
of 83,264 outputs
Outputs of similar age
#2,645
of 342,279 outputs
Outputs of similar age from Science
#112
of 1,188 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,264 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,279 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,188 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.