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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Safety and efficacy of composite collagen–silver nanoparticle hydrogels as tissue engineering scaffolds
|
|---|---|
| Published in |
Nanoscale, January 2015
|
| DOI | 10.1039/c5nr03826j |
| Pubmed ID | |
| Authors |
Emilio I. Alarcon, Klas I. Udekwu, Christopher W. Noel, Luke B.-P. Gagnon, Patrick K. Taylor, Branka Vulesevic, Madeline J. Simpson, Spyridon Gkotzis, M. Mirazul Islam, Chyan-Jang Lee, Agneta Richter-Dahlfors, Thien-Fah Mah, Erik J. Suuronen, Juan C. Scaiano, May Griffith |
| Abstract |
The increasing number of multidrug resistant bacteria has revitalized interest in seeking alternative sources for controlling bacterial infection. Silver nanoparticles (AgNPs), are amongst the most promising candidates due to their wide microbial spectrum of action. In this work, we report on the safety and efficacy of the incorporation of collagen coated AgNPs into collagen hydrogels for tissue engineering. The resulting hybrid materials at [AgNPs] < 0.4 μM retained the mechanical properties and biocompatibility for primary human skin fibroblasts and keratinocytes of collagen hydrogels; they also displayed remarkable anti-infective properties against S. aureus, S. epidermidis, E. coli and P. aeruginosa at considerably lower concentrations than silver nitrate. Further, subcutaneous implants of materials containing 0.2 μM AgNPs in mice showed a reduction in the levels of IL-6 and other inflammation markers (CCL24, sTNFR-2, and TIMP1). Finally, an analysis of silver contents in implanted mice showed that silver accumulation primarily occurred within the tissue surrounding the implant. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 93 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 21% |
| Student > Master | 10 | 11% |
| Researcher | 8 | 9% |
| Other | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 18 | 19% |
| Unknown | 26 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 10 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Agricultural and Biological Sciences | 9 | 10% |
| Medicine and Dentistry | 7 | 7% |
| Chemical Engineering | 6 | 6% |
| Other | 19 | 20% |
| Unknown | 34 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2015.
All research outputs
#15,348,897
of 22,830,751 outputs
Outputs from Nanoscale
#4,708
of 9,240 outputs
Outputs of similar age
#209,037
of 353,161 outputs
Outputs of similar age from Nanoscale
#410
of 705 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,240 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 705 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.