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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis
|
|---|---|
| Published in |
Journal of Pediatric Gastroenterology & Nutrition, April 2016
|
| DOI | 10.1097/mpg.0000000000001004 |
| Pubmed ID | |
| Authors |
Joan I. Schall, Maria R. Mascarenhas, Asim Maqbool, Kelly A. Dougherty, Okan Elci, Dah‐Jyuu Wang, Talissa A. Altes, Kevin A. Hommel, Walter Shaw, Jeff Moore, Virginia A. Stallings |
| Abstract |
Choline depletion is seen in cystic fibrosis (CF) and pancreatic insufficiency (PI) in spite of enzyme treatment and may result in liver, fatty acid and muscle abnormalities. This study evaluated the efficacy and safety of an easily absorbed choline-rich structured lipid (LYM-X-SORB [LXS]) to improve choline status. Children with CF and PI were randomized to LXS or placebo in a 12-month double blind trial. Dietary choline intake, plasma cholines, plasma and fecal phospholipids, coefficient of fat absorption (CFA), pulmonary function, growth status, body composition, and safety measures were assessed. Magnetic resonance spectroscopy for calf muscle choline and liver fat were assessed in a subgroup and compared to a healthy comparison group matched for age, sex and body size. 110 subjects were enrolled (age 10.4 ± 3.0 years). Baseline dietary choline, 88% recommended, increased 3-fold in the LXS group. Plasma choline, betaine, and dimethylglycine increased in the LXS but not placebo (P = 0.007). Plasma lysophosphatidylcholine and phosphatidylcholine (PC) increased and fecal PC/phosphatidylethanolamine ratio decreased (P ≤ 0.05) in LXS only, accompanied by a 6% CFA increase (P = 0.001). Children with CF had higher liver fat than healthy children and depleted calf muscle choline at baseline. Muscle choline concentration increased in LXS and was associated with improvement in plasma choline status. No relevant changes in safety measures were evident. LXS had improved choline intake, plasma choline status and muscle choline stores, compared with placebo. The choline-rich supplement was safe, accepted by participants and improved choline status in children with CF. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 100 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 16% |
| Student > Postgraduate | 10 | 10% |
| Student > Master | 10 | 10% |
| Student > Ph. D. Student | 8 | 8% |
| Researcher | 8 | 8% |
| Other | 14 | 14% |
| Unknown | 34 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 27% |
| Nursing and Health Professions | 16 | 16% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Sports and Recreations | 5 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 5 | 5% |
| Unknown | 38 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2017.
All research outputs
#7,994,598
of 25,461,852 outputs
Outputs from Journal of Pediatric Gastroenterology & Nutrition
#2,162
of 5,251 outputs
Outputs of similar age
#106,077
of 314,933 outputs
Outputs of similar age from Journal of Pediatric Gastroenterology & Nutrition
#23
of 66 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 5,251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,933 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.