| Title |
Glioblastoma radiomics: can genomic and molecular characteristics correlate with imaging response patterns?
|
|---|---|
| Published in |
Neuroradiology, August 2018
|
| DOI | 10.1007/s00234-018-2060-y |
| Pubmed ID | |
| Authors |
Michael H. Soike, Emory R. McTyre, Nameeta Shah, Ralph B. Puchalski, Jordan A. Holmes, Anna K. Paulsson, Lance D. Miller, Christina K. Cramer, Glenn J. Lesser, Roy E. Strowd, William H. Hinson, Ryan T. Mott, Annette J. Johnson, Hui-Wen Lo, Adrian W. Laxton, Stephen B. Tatter, Waldemar Debinski, Michael D. Chan |
| Abstract |
For glioblastoma (GBM), imaging response (IR) or pseudoprogression (PSP) is frequently observed after chemoradiation and may connote a favorable prognosis. With tumors categorized by the Cancer Genome Atlas Project (mesenchymal, classical, neural, and proneural) and by methylguanine-methyltransferase (MGMT) methylation status, we attempted to determine if certain genomic or molecular subtypes of GBM were specifically associated with IR or PSP. Patients with GBM treated at two institutions were reviewed. Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Mantel-cox test determined effect of IR and PSP on OS and PFS. Fisher's exact test was utilized to correlate IR and PSP with genomic subtypes and MGMT status. Eighty-two patients with GBM were reviewed. The median OS and PFS were 17.9 months and 8.9 months. IR was observed in 28 (40%) and was associated with improved OS (median 29.4 vs 14.5 months p < 0.01) and PFS (median 17.7 vs 5.5 months, p < 0.01). PSP was observed in 14 (19.2%) and trended towards improved PFS (15.0 vs 7.7 months p = 0.08). Tumors with a proneural component had a higher rate of IR compared to those without a proneural component (IR 60% vs 28%; p = 0.03). MGMT methylation was associated with IR (58% vs 24%, p = 0.032), but not PSP (34%, p = 0.10). IR is associated with improved OS and PFS. The proneural subtype and MGMT methylated tumors had higher rates of IR. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 18% |
| Student > Ph. D. Student | 6 | 14% |
| Student > Bachelor | 4 | 9% |
| Researcher | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 5 | 11% |
| Unknown | 16 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Neuroscience | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 18 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2018.
All research outputs
#18,809,260
of 23,310,485 outputs
Outputs from Neuroradiology
#941
of 1,414 outputs
Outputs of similar age
#255,410
of 331,620 outputs
Outputs of similar age from Neuroradiology
#14
of 37 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,414 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,620 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.