| Title |
Effects of post-remission chemotherapy before allo-HSCT for acute myeloid leukemia during first complete remission: a meta-analysis
|
|---|---|
| Published in |
Annals of Hematology, June 2018
|
| DOI | 10.1007/s00277-018-3414-6 |
| Pubmed ID | |
| Authors |
Yangmin Zhu, Qingyan Gao, Jun Du, Jing Hu, Xu Liu, Fengkui Zhang |
| Abstract |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is most frequently used to treat acute myeloid leukemia (AML). Whether patients should routinely receive consolidation chemotherapy before proceeding to transplant after achieving first complete remission (CR1) has been a subject of debate. We performed a systematic review and meta-analysis of studies examining the impact of post-remission chemotherapy before allo-HSCT in patients with AML in CR1. Six studies including 1659 patients were included in the meta-analysis. The pooled hazard ratio (HR) for overall survival was 0.9 (95% confidence interval [CI] 0.77-1.05, P = 0.182), and the pooled HR for leukemia-free survival was 0.87 (95% CI 0.75-1.0, P = 0.07). No survival advantage was observed for post-remission chemotherapy before reduced-intensity conditioning or myeloablative conditioning (MAC) allo-HSCT for AML in CR1. The pooled relative risk for relapse incidence (RI) was 1.02 (95% CI 0.82-1.28, P = 0.834). Post-remission chemotherapy before allo-HSCT did not significantly affect the RI in patients with AML in CR1. The analyses revealed no significant benefit of post-remission consolidation chemotherapy in patients who received allo-HSCT. We recommend proceeding to allo-HSCT as soon as CR1 is attained. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 21% |
| Spain | 4 | 9% |
| India | 4 | 9% |
| France | 3 | 7% |
| United Kingdom | 3 | 7% |
| Canada | 2 | 5% |
| Brazil | 2 | 5% |
| Paraguay | 2 | 5% |
| Nepal | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 11 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 58% |
| Scientists | 12 | 28% |
| Practitioners (doctors, other healthcare professionals) | 5 | 12% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 16% |
| Lecturer | 2 | 11% |
| Student > Master | 2 | 11% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Other | 4 | 21% |
| Unknown | 6 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 42% |
| Nursing and Health Professions | 3 | 16% |
| Engineering | 1 | 5% |
| Unknown | 7 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#1,492,872
of 25,658,139 outputs
Outputs from Annals of Hematology
#35
of 2,434 outputs
Outputs of similar age
#31,007
of 343,378 outputs
Outputs of similar age from Annals of Hematology
#2
of 51 outputs
Altmetric has tracked 25,658,139 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,434 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.