Title |
Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma
|
---|---|
Published in |
Cancer and Metastasis Reviews, August 2018
|
DOI | 10.1007/s10555-018-9751-z |
Pubmed ID | |
Authors |
K. Slater, P. S. Hoo, A. M. Buckley, J. M. Piulats, A. Villanueva, A. Portela, B. N. Kennedy |
Abstract |
Uveal melanoma is a rare, but deadly, form of eye cancer that arises from melanocytes within the uveal tract. Although advances have emerged in treatment of the primary tumour, patients are still faced with vision loss, eye enucleation and lethal metastatic spread of the disease. Approximately 50% of uveal melanoma patients develop metastases, which occur most frequently in the liver. Metastatic patients encounter an extremely poor prognosis; as few as 8% survive beyond 2 years. Understanding of the genetic underpinnings of this fatal disease evolved in recent years with the identification of new oncogenic mutations that drive uveal melanoma pathogenesis. Despite this progress, the lack of successful therapies or a proven standard-of-care for uveal melanoma highlights the need for new targeted therapies. This review focuses on the recently identified CYSLTR2 oncogenic mutation in uveal melanoma. Here, we evaluate the current status of uveal melanoma and investigate how to better understand the role of this CYSLTR2 mutation in the disease and implications for patients harbouring this mutation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 6 | 40% |
United Kingdom | 2 | 13% |
United States | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 87% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 19% |
Student > Master | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Other | 3 | 8% |
Other | 5 | 14% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 35% |
Medicine and Dentistry | 10 | 27% |
Agricultural and Biological Sciences | 3 | 8% |
Neuroscience | 1 | 3% |
Chemistry | 1 | 3% |
Other | 0 | 0% |
Unknown | 9 | 24% |